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LYRICA

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Generic Name for LYRICA

Pregabalin 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg; caps.

Legal Classification:

CV

Pharmacological Class for LYRICA

α2-delta ligand.

Manufacturer of LYRICA

Pfizer Inc.

Indications for LYRICA

Fibromyalgia.

Other Indications for LYRICA

Adult dose for LYRICA

≥18yrs: initially 75mg twice daily, may increase to 150mg twice daily within 1 week as tolerated; max 450mg/day. Renal impairment (CrCl <60mL/min): reduce dose (see literature); hemodialysis: give supplemental dose after session.

Children's dosing for LYRICA

<18yrs: not recommended.

Warnings/Precautions for LYRICA

Avoid abrupt cessation (taper over ≥1 week). Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. CHF. Ocular conditions. Diabetes (monitor skin integrity). Suicidal tendencies (monitor). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions for LYRICA

Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones.

Adverse Reactions for LYRICA

Dizziness, somnolence, other CNS effects, dry mouth, edema, ocular/visual effects (eg, blurring), weight gain, infection, asthenia, paresthesias, elevated creatine kinase, decreased platelets, arrhythmias (PR prolongation); male-mediated teratogenicity; may be tumorigenic.

How is LYRICA supplied?

Caps—90

Related Disease:

Fibromyalgia

Related Resources

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Pregabalin is an effective treatment for patients who experience below-level neuropathic pain following a spinal cord injury, according to data presented at the American Pain Society's 31st Annual Scientific Meeting.

Severity of Sleep Interference Due to Neuropathic Pain May Be Predictive of Response to Pregabalin

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Severity of sleep disturbance in patients with painful diabetic peripheral neuropathy (DPN) or post-herpetic neuralgia (PHN) may be predictive of patient response to pregabalin treatment for neuropathic pain reduction, a presentation at the American Pain Society's 31st Annual Scientific Meeting has found.

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May 17, 2012

The percentage of patients in community-practice settings who newly initiate opioid therapy while taking gabapentin and pregabalin for postherpetic neuralgia suggest these agents should be titrated to higher and potentially more effective dosages, a study presented at the American Pain Society's 31st Annual Scientific Meeting has found.

Pregabalin Rapidly Improves Sleep in Painful Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

May 17, 2012

Patients with diabetic peripheral neuropathy (DPN) or postherpetic neuralgia (PHN) treated with pregabalin have rapid, significant, and sustained improvement in sleep, according to a posthoc analysis of 16 placebo-controlled trials of pregabalin in 4,527 patients reported during the American Pain Society's 31st Annual Scientific Meeting.

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May 01, 2012

Pain catastrophizing, in particular ruminating about pain, has an indirect effect on clinical pain severity and pain-related interference, through sleep disturbance.

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Updated: 5/8/2012

 

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Monograph added.

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