LUVOX CR
Generic Name for LUVOX CR
Fluvoxamine maleate 100mg, 150mg; ext-rel caps.
Legal Classification:
Rx
Pharmacological Class for LUVOX CR
SSRI.
Manufacturer of LUVOX CR
Jazz Pharmaceuticals
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Indications for LUVOX CR
Obsessive-compulsive disorder. Social anxiety disorder.
Adult dose for LUVOX CR
Swallow whole. ≥18yrs: initially 100mg once daily at bedtime; may increase in 50mg increments at 1-week interval; range 100–300mg/day; max 300mg/day. Hepatic impairment: initially 100mg and titrate slowly.
Children's dosing for LUVOX CR
Not recommended.
Contraindications for LUVOX CR
Concomitant alosetron, tizanidine, pimozide, thioridazine, ramelteon. During or within 14 days of MAOIs.
Warnings/Precautions for LUVOX CR
Liver dysfunction. History of seizures (discontinue if occurs), mania/hypomania, or drug abuse. ECT. Cardiovascular disease. Diseases that affect metabolism or hemodynamic response. SIADH, edema, fluid loss, adrenal disorders, displacement syndromes (monitor electrolytes, BUN, creatinine). Reduced activity of CYP2D6. Suicidal tendencies. Reevaluate periodically. Write ℞ for smallest practical amount. Avoid abrupt cessation. Elderly. Labor & delivery. Pregnancy (Cat.C); 3rd trimester: consider tapering dose. Nursing mothers: not recommended.
Interactions for LUVOX CR
See Contraindications. Prolongation of QT interval with pimozide, thioridazine. Avoid alcohol. Potentiated by other serotonergic drugs, sumatriptan, lithium, tramadol, St. John's Wort. Concomitant other SSRIs, SNRIs, or tryptophan: not recommended. Potentiates diazepam (not recommended), triazolam and alprazolam (reduce their doses by at least ½), midazolam, theophylline (reduce its dose by ⅔ and monitor), warfarin, carbamazepine, tricyclic antidepressants (reduce their doses and monitor), propranolol, metoprolol (reduce their doses), clozapine, methadone, tacrine. Caution with drugs that inhibit CYP2D6 (eg, quinidine) or 3A4, phenytoin, diltiazem. Caution with aspirin, NSAIDs, warfarin, other anticoagulants (increased risk of bleeding). Monitor mexiletine levels. Smokers may have increased metabolism.
Adverse Reactions for LUVOX CR
Headache, somnolence, insomnia, nervousness, tremor, GI upset, anorexia, dry mouth, abnormal ejaculation, asthenia, sweating, decreased libido, rhinitis, anorgasmia, taste perversion; agitation, irritability, and behavioral changes (monitor).
How is LUVOX CR supplied?
Caps—30
Related Disease:
Obsessive-compulsive disorder
Social anxiety disorder