Compare
LOPRESSOR INJECTION to:
Generic Name for LOPRESSOR INJECTION
Metoprolol tartrate 5mg; soln for IV inj.
Legal Classification:
Rx
Pharmacological Class for LOPRESSOR INJECTION
β-blocker.
Manufacturer of LOPRESSOR INJECTION
Novartis Pharmaceuticals Corp
|
Indications for LOPRESSOR INJECTION
In stabilized patients after MI, to reduce mortality.
Adult dose for LOPRESSOR INJECTION
See literature. Early treatment: initially administer three 5mg IV bolus inj given at approximately 2-minute intervals; monitor BP, HR, ECG. If full IV dose (15mg) tolerable, give 50mg (tab) every 6 hours starting 15 mins after the last IV dose and continue for 48 hours, thereafter, give maintenance dose of 100mg (tab) twice daily; if full IV dose not tolerable, give 25–50mg (tab) every 6 hours starting 15 mins after the last IV dose or as soon as clinical condition allows; if severe intolerance: discontinue treatment. Late treatment: if early phase treatment is contraindicated, intolerable or delayed therapy needed, start with 100mg (tab) twice daily for at least three months.
Children's dosing for LOPRESSOR INJECTION
Not recommended.
Also:
Contraindications for LOPRESSOR INJECTION
Significant 1st degree heart block. 2nd- or 3rd-degree AV block. Systolic pressure<100mmHg or heart rate <45 beats/min. Moderate-to-severe cardiac failure.
Warnings/Precautions for LOPRESSOR INJECTION
CHF. Bronchospastic disease. Hepatic dysfunction. Diabetes. Pheochromocytoma. Hyperthyroidism. Surgery. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.
Interactions for LOPRESSOR INJECTION
Bradycardia with catecholamine-depleting drugs. May be potentiated by potent CYP2D6 inhibitors (eg, fluoxetine, paroxetine, bupropion, thioridazine, quinidine, propafenone, ritonavir, diphenhydramine, hydroxychloroquine, terbinafine, cimetidine), inhalation anesthetics. Increased risk of bradycardia with concomitant digitalis. May block epinephrine. Increased rebound hypertension with clonidine withdrawal.
Adverse Reactions for LOPRESSOR INJECTION
Fatigue, dizziness, depression, hypotension (discontinue if occurs), diarrhea, rash, dyspnea, bradycardia, cold extremities, palpitations, CHF, peripheral edema, bronchospasm, heart block.
How is LOPRESSOR INJECTION supplied?
Tabs—100; Ampuls (5mL)—10