Select therapeutic use:
Indications for LIBRIUM:
Individualize. Mild-to-moderate: 5–10mg 3–4 times daily. Severe: 20–25mg 3–4 times daily. Elderly or debilitated: 5mg 2–4 times daily.
<6yrs: not recommended. ≥6yrs: 5mg 2–4 times daily. May increase to 10mg 2–3 times daily.
Risks from concomitant use with opioids; see Interactions. Therapy for >4 months. Suicidal tendencies. Depression. Psychosis. Porphyria. Seizure disorder. Monitor blood counts and liver function. Reevaluate periodically. Abuse potential (monitor). Drug or alcohol abuse. Avoid abrupt cessation. Change dose gradually. Renal or hepatic impairment. Elderly. Debilitated. Pregnancy (during the 1st trimester), nursing mothers: not recommended.
Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants. Variable effects with anticoagulants. Avoid other psychotropics.
Drowsiness, CNS depression, ataxia, confusion, paradoxical excitement, memory impairment, nausea, constipation, blood dyscrasias, jaundice, skin eruptions, edema, extrapyramidal effects.