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Bacterial infections
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Generic Name and Formulations:

Clofazimine 50mg; soft gel caps.

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Indications for LAMPRENE:

Lepromatous leprosy, including dapsone-resistant, and/or complicated by erythema nodosum leprosum.


Take with meals. Dapsone-sensitive: 100mg daily with 2 other antileprosy drugs for ≥2 years until skin smears negative, then use antileprosy monotherapy. Dapsone-resistant: 100mg daily with ≥1 other antileprosy drug for 3 years, then 100mg daily as monotherapy. Erythema nodosum: 100–200mg daily in combination with baseline antileprosy treatment and steroids as clinically indicated; if administered at 200mg dose, taper to 100mg as soon as possible; see full labeling.


Not established.


Abdominal obstruction and other GI disorders (eg, abdominal pain, nausea, vomiting, diarrhea); if occurs, consider reducing dose, increasing dosing interval, or discontinuing. QT prolongation: monitor ECGs. Psychological effects of skin discoloration: monitor for depression or suicidal ideation. Elderly. Pregnancy; verify status prior to initiation. Females of reproductive potential should use effective contraception and males (condoms) during treatment and for at least 4 months after completion. Nursing mothers: not recommended.


Dapsone may inhibit antiinflammatory activity. Concomitant with other QT prolonging drugs or with bedaquiline may cause additive QT prolongation.

Pharmacological Class:


Adverse Reactions:

Skin and body fluid discoloration (conjunctivae, tears, urine, fecal, sputum, or sweat), ichthyosis, dryness, rash, pruritus, diarrhea, nausea, vomiting, GI intolerance, abdominal/epigastric pain; elevated blood glucose or ESR; QT prolongation, Torsades de Pointes.

How Supplied: