LAMISIL TABLETS Rx

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LAMISIL TABLETS

Fungal infections
Only 4 drugs may be compared at once

Generic Name and Formulations:

Terbinafine HCl 250mg.

Select therapeutic use:

Indications for LAMISIL TABLETS:

Onychomycosis of the toenail or fingernail due to tinea unguium.

Adult:

250mg once daily for 6 weeks (fingernail) or 12 weeks (toenail).

Children:

Not established.

Contraindications:

Chronic or active liver disease.

Warnings/Precautions:

Onychomycosis: confirm diagnosis with nail specimen. Pre-existing hepatic disease or renal impairment (CrCl <50mL/min): not recommended. Perform LFTs prior to and periodically during treatment. Discontinue if hepatic injury, progressive skin rash (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS), taste/smell disturbances, severe neutropenia (neutrophils ≤1000 cells/mm3), thrombotic microangiopathy occurs, or if lupus erythematosus is suspected. Monitor CBCs if immunodeficient. Pregnancy (Cat.B), nursing mothers: not recommended.

Interactions:

Potentiated by cimetidine. Antagonized by rifampin. May potentiate drugs metabolized by CYP2D6 (eg, tricyclic antidepressants, SSRIs, beta-blockers). May be potentiated by CYP2C9 and CYP3A4 inhibitors (eg, fluconazole, ketoconazole, amiodarone). Potentiates caffeine. Antagonizes cyclosporine.

See Also:

LAMISIL ORAL GRANULES

Pharmacological Class:

Allylamine antifungal.

Adverse Reactions:

Headache, diarrhea, rash, dyspepsia, liver enzyme abnormalities, pruritus, taste disturbances, nausea, abdominal pain, flatulence, urticaria; also children: nasopharyngitis, pyrexia, cough, upper respiratory infection; rare: hepatotoxicity, depressive symptoms, smell disturbances.

How Supplied:

Tabs—30, 100; Packets—14, 42