Osteoarthritis. Rheumatoid arthritis.
NSAID (propionic acid deriv.).
Aspirin allergy. Late pregnancy. Coronary artery bypass graft surgery.
Advanced renal disease: not recommended. Acute pain. Renal or hepatic dysfunction. Edema. Hypertension. Cardiac failure. History of upper GI disease. Bleeding disorders. Hypoalbuminemia. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended.
Avoid salicylates, probenecid. Renal toxicity potentiated with diuretics. Monitor oral anticoagulants. May increase toxicity of methotrexate. May increase serum lithium levels.
GI bleeding, peptic ulcer, peripheral edema, dyspepsia, headache, dizziness, drowsiness, nausea, abdominal pain, diarrhea, constipation, flatulence, rash (discontinue if occurs), tinnitus, visual disturbances, GI or CNS disturbances, nephrotoxicity, jaundice. See literature re: risk of cardiovascular events.
Formerly known under the brand name Oruvail.