Susceptible infections including otitis media, skin and skin structure, bone, respiratory or genitourinary tract.
1–4g/day in divided doses. Usual dose: 250mg every 6 hours. Strep pharyngitis, skin and skin structure, and uncomplicated cystitis (>15 years of age): 500mg every 12 hours. Treat cystitis for 7–14 days. Max 4g/day.
25–50mg/kg per day in divided doses; max 100mg/kg per day. Otitis media: 75–100mg/kg per day in 4 divided doses. Strep pharyngitis (>1 year of age) or skin and skin structure: may give in 2 divided doses every 12 hours.
Penicillin or other allergy. Severe renal dysfunction. GI disease (esp. colitis). Discontinue if colitis occurs and treat. Pregnancy (Cat.B). Nursing mothers.
Potentiates metformin (monitor and adjust metformin dose). Potentiated by probenecid. May cause false (+) Coomb's test or glucose test with Clinitest or Benedict's or Fehling's soln.
Diarrhea, other GI disturbances, dizziness, fatigue, headache, hypersensitivity reactions, itch; rare: blood dyscrasias, elevated liver enzymes.
Caps 250mg, 500mg—20, 100; 750mg—50