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Generic Name and Formulations:

Clonidine HCl 0.1mg, 0.2mg; extended-release tablets.

Select therapeutic use:

Indications for KAPVAY:

Attention deficit hyperactivity disorder (ADHD).


Not recommended.


<6yrs: not recommended. Swallow whole. Titrate by response. Initially 0.1mg at bedtime for 1 week, then 0.1mg twice daily for 1 week, then 0.1mg in the morning and 0.2mg at bedtime for 1 week, then 0.2mg twice daily. Withdraw gradually; reduce by 0.1mg/day at 3–7 day intervals. Renal dysfunction: may need reduced dose.


Hypotension, bradycardia, heart block, vascular disease, cardio- or cerebrovascular disease, chronic renal failure, conduction disturbances: uptitrate slowly and monitor. History of, or conditions that predispose to syncope. Monitor pulse, BP. Maintain adequate hydration. Reevaluate periodically. Pregnancy (Category C). Nursing mothers.

Pharmacological Class:

Central alpha-2 agonist.


Potentiates alcohol, other CNS depressants, antihypertensives. Hypotensive effect may be antagonized by tricyclic antidepressants. Additive AV block, bradycardia with drugs that affect cardiac conduction (eg, digitalis, calcium channel blockers, β-blockers). Avoid other forms of clonidine. May need to adjust dose of concurrent stimulant medication.

Adverse Reactions:

Somnolence, fatigue, upper respiratory tract infection, irritability, sore throat, insomnia, nightmares, emotional disorder, constipation, nasal congestion, fever, dry mouth, ear pain.

How Supplied:

Tabs—60, 180

KAPVAY 0.1mg tablets (Qty:60)

appx. price $460.00