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ISENTRESS
Viral infections
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Drug Name:

ISENTRESS Rx

Generic Name and Formulations:
Raltegravir (as potassium) 25mg, 100mg+; chew tabs; scored (+); orange-banana flavored; contains phenylalanine; 400mg; film-coated tabs.

Company:
Merck & Co., Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

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RECENT UPDATES

06/24/14
Indication and dosing expanded to include children =4 weeks.

Indications for ISENTRESS:

HIV-1 infection, in combination with other antiretrovirals.

Adult Dose for ISENTRESS:

Film-coated tabs: swallow whole. 400mg twice daily. Avoid dosing before dialysis sessions. Concomitant rifampin: 800mg twice daily.

Children's Dose for ISENTRESS:

See full labeling. <4 weeks: not established. ≥4 weeks (≥25kg): one 400mg film-coated tab twice daily. If unable to swallow, can use chew tabs: (25–<28kg): 150mg twice daily; (28–<40kg): 200mg twice daily; ≥40kg: 300mg twice daily. Chew tabs max dose: 300mg twice daily.

See Also:

ISENTRESS ORAL SUSPENSION

Pharmacological Class:

HIV-1 integrase strand transfer inhibitor.

Warnings/Precautions:

Chew tabs or oral susp are not interchangeable with the film-coated tabs. Severe hepatic impairment. Monitor liver aminotransferases, immune reconstitution syndrome (esp. during initial therapy), myopathy, and rhabdomyolysis. Discontinue if signs/symptoms of severe skin or hypersensitivity reactions develop. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Antagonized by rifampin, possibly other strong UGT1A1 inducers. May be potentiated by UGT1A1 inhibitors. Concomitant aluminum and/or magnesium-containing antacids: not recommended. Caution with other drugs that can cause myopathy (eg, statins).

Adverse Reactions:

Insomnia, headache, dizziness, nausea, asthenia, fatigue, creatinine kinase elevations, myopathy, rhabdomyolysis; severe skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), hypersensitivity, others (see full labeling).

Note:

Note: Register pregnant patients exposed to raltegravir by calling (800) 258-4263.

How Supplied:

Chew tabs, film-coated tabs—60; Susp (pkts)—1, 60 (w. syringes, mixing cups)

ISENTRESS

  • 400mg tablets (Qty:60)
  • appx. price $1204.00
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