Indications for ISENTRESS:
HIV-1 infection, in combination with other antiretrovirals.
Adult Dose for ISENTRESS:
Film-coated tabs: swallow whole. 400mg twice daily. Avoid dosing before dialysis sessions. Concomitant rifampin: 800mg twice daily.
Children's Dose for ISENTRESS:
<2yrs: not recommended. 2–<6yrs (and ≥10kg): use chew tabs and base dose on weight. 6–<12yrs: one 400mg film-coated tab twice daily or use chew tabs and base dose on weight; if 10–<14kg: 75mg twice daily; 14–<20kg: 100mg twice daily; 20–<28kg: 150mg twice daily; 28–<40kg: 200mg twice daily; ≥40kg: 300mg twice daily. Chew tab max dose: 300mg twice daily. ≥12yrs: one 400mg film-coated tab twice daily.
Pharmacological Class:
HIV-1 integrase strand transfer inhibitor.
Warnings/Precautions:
Chew tabs and film-coated tabs are not interchangeable. Severe hepatic impairment. Monitor liver aminotransferases, immune reconstitution syndrome (esp. during initial therapy), myopathy, and rhabdomyolysis. Discontinue if signs/symptoms of severe skin or hypersensitivity reactions develop. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions:
Antagonized by rifampin, possibly other strong UGT1A1 inducers. May be potentiated by UGT1A1 inhibitors. Caution with other drugs that can cause myopathy (eg, statins).
Adverse Reactions:
Insomnia, headache, nausea, asthenia, fatigue, creatinine kinase elevations, myopathy, rhabdomyolysis; severe skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), hypersensitivity, others (see literature).
Note:
Register pregnant patients exposed to raltegravir by calling (800) 258-4263.
How Supplied:
Chew tabs, film-coated tabs—60
