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Drug Name:


Generic Name and Formulations:
Raltegravir (as potassium) 25mg, 100mg+; chew tabs; scored (+); contain phenylalanine; 400mg; film-coated tabs.

Merck & Co., Inc.

e-Prescribe this drug via Surescripts

Therapeutic Use:

Indications for ISENTRESS:

HIV-1 infection, in combination with other antiretrovirals.

Adult Dose for ISENTRESS:

Film-coated tabs: swallow whole. 400mg twice daily. Avoid dosing before dialysis sessions. Concomitant rifampin: 800mg twice daily.

Children's Dose for ISENTRESS:

<2yrs: not recommended. 2–<6yrs (and ≥10kg): use chew tabs and base dose on weight. 6–<12yrs: one 400mg film-coated tab twice daily or use chew tabs and base dose on weight; if 10–<14kg: 75mg twice daily; 14–<20kg: 100mg twice daily; 20–<28kg: 150mg twice daily; 28–<40kg: 200mg twice daily; ≥40kg: 300mg twice daily. Chew tab max dose: 300mg twice daily. ≥12yrs: one 400mg film-coated tab twice daily.

Pharmacological Class:

HIV-1 integrase strand transfer inhibitor.


Chew tabs and film-coated tabs are not interchangeable. Severe hepatic impairment. Monitor liver aminotransferases, immune reconstitution syndrome (esp. during initial therapy), myopathy, and rhabdomyolysis. Discontinue if signs/symptoms of severe skin or hypersensitivity reactions develop. Pregnancy (Cat.C). Nursing mothers: not recommended.


Antagonized by rifampin, possibly other strong UGT1A1 inducers. May be potentiated by UGT1A1 inhibitors. Caution with other drugs that can cause myopathy (eg, statins).

Adverse Reactions:

Insomnia, headache, nausea, asthenia, fatigue, creatinine kinase elevations, myopathy, rhabdomyolysis; severe skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), hypersensitivity, others (see literature).


Register pregnant patients exposed to raltegravir by calling (800) 258-4263.

How Supplied:

Chew tabs, film-coated tabs—60

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