Select the drug indication to add to your list


Viral infections
Only 4 drugs may be compared at once

Generic Name and Formulations:

Raltegravir (as potassium) 25mg, 100mg+; chew tabs; scored (+); orange-banana flavored; contains phenylalanine; 400mg; film-coated tabs.

Select therapeutic use:

Indications for ISENTRESS:

HIV-1 infection, in combination with other antiretrovirals.


Film-coated tabs: swallow whole. 400mg twice daily. Avoid dosing before dialysis sessions. Concomitant rifampin: 800mg twice daily.


See full labeling. <4 weeks: not established. ≥4 weeks (≥25kg): one 400mg film-coated tab twice daily. If unable to swallow, can use chew tabs: (25–<28kg): 150mg twice daily; (28–<40kg): 200mg twice daily; ≥40kg: 300mg twice daily. Chew tabs max dose: 300mg twice daily.


Chew tabs or oral susp are not interchangeable with the film-coated tabs. Severe hepatic impairment. Monitor liver aminotransferases, immune reconstitution syndrome (esp. during initial therapy), myopathy, and rhabdomyolysis. Discontinue if signs/symptoms of severe skin or hypersensitivity reactions develop. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.


Antagonized by rifampin, possibly other strong UGT1A1 inducers. May be potentiated by UGT1A1 inhibitors. Concomitant aluminum and/or magnesium-containing antacids: not recommended. Caution with other drugs that can cause myopathy (eg, statins).

See Also:


Pharmacological Class:

HIV-1 integrase strand transfer inhibitor (INSTI).

Adverse Reactions:

Insomnia, headache, dizziness, nausea, asthenia, fatigue, creatinine kinase elevations, myopathy, rhabdomyolysis; severe skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), hypersensitivity, others (see full labeling).


Note: Register pregnant patients exposed to raltegravir by calling (800) 258-4263.

How Supplied:

Chew tabs, film-coated tabs—60; Susp (pkts)—1, 60 (w. syringes, mixing cups)

ISENTRESS 400mg tablets (Qty:60)

appx. price $1394.00