IRRITABLE BOWEL SYNDROME TREATMENTS
 
Generic & Class Strength Brand & Company   Formulations* Usual Dose
5-HT3 RECEPTOR ANTAGONIST
alosetron HCl 0.5mg, 1mg LOTRONEX
Prometheus Labs		 Rx tabs Adults: Initially 0.5mg twice daily. May increase to 1mg twice daily after 4wks if starting dose is tolerated but inadequate. Discontinue if inadequate control of symptoms after 4wks of treatment at 1mg twice daily. If constipation occurs, discontinue until constipation resolves, then restart at 0.5mg once daily. If constipation recurs, discontinue immediately.
Children: Not recommended
ANTICHOLINERGIC
1-hyoscyamine sulfate 0.125mg ANASPAZ
Ascher, B.F. & Co.		 Rx ODT Adults and children: <2yrs: not recommended. 2–12yrs: ½–1 tab every 4hrs or as needed; max 6 tabs/24hrs. ≥12yrs: 1–2 tabs every 4hrs or as needed; max 12 tabs/24hrs. Tabs may be swallowed, chewed, or dissolved sublingually.
dicyclomine HCl 10mg BENTYL
Aptalis Pharmaceutical Technologies		 Rx caps Adults: Initially 20mg 4 times daily; increase to 40mg 4 times daily if tolerated. Discontinue if not effective within 2wks or daily doses ≥80mg are not tolerated.
Children: <6months: not recommended. ≥6months: consult manufacturer.
20mg tabs
10mg/5mL BENTYL SYRUP
Aptalis Pharmaceutical Technologies		 syrup
hyoscyamine sulfate 0.125mg LEVSIN
Alaven		 Rx tabs+ Adults: 1–2 tabs or 5–10mL every 4hrs or as needed; max 12 tabs or 60mL daily.
Children: Use drops.
0.125mg/mL LEVSIN DROPS1
Alaven		 liq Adults: 1–2mL every 4hrs or as needed; max 12mL/day.
Children: 3.4kg: 4 drops. 5kg: 5 drops. 7kg: 6 drops. 10kg: 8 drops. Older children (2yrs–12yrs): 0.25–1mL; max 6mL/day. All: every 4hrs or as needed.
0.125mg LEVSIN/SL2
Alaven		 SL tabs+ Adults: 1–2 tabs sublingually, swallowed, or chewed every 4hrs or as needed; max 12 tabs/day.
Children: <2yrs: not recommended. ≥2yrs: ½–1 tab every 4hrs or as needed; max 6 tabs/day.
0.125mg NULEV
Alaven		 Rx chewable melt tabs Adults and children: <2yrs: not recommended. 2–12yrs: ½–1 tab every 4hrs or as needed; max 6 tabs/day. ≥12yrs: 1–2 tabs every 4hrs or as needed; max 12 tabs/day. Tabs may be chewed or dissolved on tongue and swallowed.
BARBITURATE + ANTICHOLINERGICS
phenobarbital 16.2mg/5mL DONNATAL ELIXIR1
PBM Pharmaceuticals		 Rx liq Adults: 5–10mL 3–4 times daily.
Children: <10lb (4.5kg): not recommended. 10lb (4.5kg): Initially 0.5mL every 4hrs or 0.75mL every 6hrs. 20lb (9.1kg): 1mL every 4hrs or 1.5mL every 6hrs. 30lb (13.6kg): 1.5mL every 4hrs or 2mL every 6hrs. 50lb (22.7kg): 2.5mL every 4hrs or 3.75mL every 6hrs. 75lb (34kg): 3.75mL every 4hrs or 5mL every 6hrs. 100 lb (45.4kg): 5mL every 4hrs or 7.5mL every 6hrs.
hyoscyamine sulfate 0.1037mg/5mL
atropine sulfate 0.0194mg/5mL
scopolamine HBr 0.0065mg/5mL
phenobarbital 48.6mg DONNATAL EXTENTABS
PBM Pharmaceuticals		 Rx ext-rel tabs Adults: 1 tab every 8–12hrs.
Children: Not recommended
hyoscyamine sulfate 0.3111mg
atropine sulfate 0.0582mg
scopolamine HBr 0.0195mg
phenobarbital 16.2mg DONNATAL TABLETS
PBM Pharmaceuticals		 Rx tabs Adults: 1–2 tabs 3–4 times daily.
Children: Not recommended
hyoscyamine sulfate 0.1037mg
atropine sulfate 0.0194mg
scopolamine HBr 0.0065mg
BENZODIAZEPINE + ANTICHOLINERGIC
chlordiazepoxide HCl 5mg LIBRAX
Valeant		 CIV caps Adults: 1–2 caps 3–4 times daily before meals and at bedtime. Elderly or debilitated: max 2 caps daily initially, then may increase gradually.
Children: Not recommended
clidinium bromide 2.5mg
GI MOTILITY ENHANCER (CHLORIDE CHANNEL ACTIVATOR)
lubiprostone 8micrograms, 24micrograms AMITIZA
Sucampo and Takeda		 Rx caps ≥18yrs: Take with food and water. 8micrograms twice daily.
<18yrs: Not recommended
NOTES

*caps = capsules; ext-rel = extended release; liq = liquid; ODT = orally disintegrating tablets; tabs = tablets; SL = sublingual; +scored

1Contains alcohol  2Dye-free

(Rev. 2/2012)