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Generic Name and Formulations:

Apraclonidine (as HCl) 0.5%; oph. soln; contains benzalkonium chloride.

Select therapeutic use:

Indications for IOPIDINE:

Short-term adjunctive therapy to reduce elevated IOP.


Remove contact lenses; may reinsert 15min after instillation. 1–2 drops 3 times daily. Allow at least 5min between instillation of other oph drugs.


Not established.


Clonidine allergy. Concomitant MAOIs.


Monitor visual fields. Severe uncontrolled cardiovascular disease, hypertension, coronary insufficiency. Recent myocardial infarction. Cerebrovascular disease. Raynaud's syndrome. Thromboangiitis obliterans. Discontinue if ocular allergic-like reactions occur. Renal or hepatic impairment: closely monitor cardiovascular parameters. Depression. Masks hypoglycemia. Pregnancy. Nursing mothers.


Hypertensive crisis with MAOIs. May potentiate CNS depressants, alcohol. May be antagonized by tricyclic antidepressants. Additive hypotensive effects with neuroleptics; hypotensive and pulse effects with β-blockers, antihypertensives, cardiac glycosides, others (eg, clonidine).

Pharmacological Class:

Alpha-2 agonist.

Adverse Reactions:

Hyperemia, pruritus, dry mouth, itching, discomfort, tearing, dizziness, solmnolence, lid edema, blurred vision, foreign body sensation, dry eye, conjunctivitis, discharge, blanching, headache, asthenia, dry nose, taste perversion; tachyphylaxis may develop after 1 month.

Generic Availability:


How Supplied:

Soln—5mL, 10mL

IOPIDINE 0.1ml of 1% eye droppers (Qty:240)

appx. price $666.00