Susceptible moderate to severe infections including complicated intraabdominal, complicated skin and skin structure, community-acquired pneumonia, complicated UTIs, acute pelvic infections. Prevention of surgical site infection following elective colorectal surgery in adults.
Give by IV infusion over 30 minutes for up to 14 days; or, give by IM inj for up to 7 days (for IM: see note). <3months: not recommended. 3months–12yrs: 15mg/kg twice daily (max 1g/day). ≥13yrs: 1g once daily; renal dysfunction (CrCl ≤30mL/min): 500mg once daily (give supplemental 150mg after session if dosed within 6 hours of hemodialysis). Intraabdominal: treat 5–14 days. Skin and skin structure: treat 7–14 days. Pneumonia, UTIs: treat 10–14 days (may switch to oral antibiotic after 3 days). Pelvic: treat 3–10 days. Adult prophylaxis in colorectal surgery: 1g single IV dose given 1 hour prior to surgical incision.
Penicillin, cephalosporin, or other β-lactam allergy.
CNS disorders (eg, brain lesions, seizure history). Renal dysfunction. Avoid extravasation. Monitor renal, hepatic, and hematopoetic function in prolonged use. Elderly. Labor & delivery. Pregnancy (Cat.B). Nursing mothers.
Potentiated by probenecid: not recommended. Antagonizes valproic acid or divalproex sodium: not recommended; consider other antibacterials.
GI upset, inj site reactions (thrombophlebitis/phlebitis), headache, CNS effects (dizziness, altered mental state, rarely: seizures), edema, dyspnea, fever.
For IM use, reconstitute with lidocaine 1% only; see literature.