Insulins
| INSULINS | ||||||||
|---|---|---|---|---|---|---|---|---|
|
Insulin products available and defined according
to derivation, onset*, peak, and duration** of action.
|
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| Preparation | Brand | Manufacturer | Route | Onset (hours) |
Peak (hours) |
Duration (hours) |
Source | |
| Insulin Aspart | NovoLog² | Rx | Novo Nordisk | SC, IV, CSII | ≤0.25 | 1–3 | 3–5 | human |
| Insulin Aspart Protamine/
Insulin Aspart |
NovoLog Mix 70/30² | Rx | Novo Nordisk | SC | ≤0.25 | 2.4 | 24 | human |
| Insulin Detemir | Levemir² | Rx | Novo Nordisk | SC | 1 | none | 24 | human |
| Insulin Glargine | Lantus³ | Rx | Sanofi Aventis | SC | 1.1 | none | ≥24 | human |
| Insulin Glulisine | Apidra³ | Rx | Sanofi Aventis | SC, CSII, IV*** | ≤0.25 | 1 | 2–4 | human |
| Insulin Lispro | Humalog³ | Rx | Lilly | SC, CSII | ≤0.25 | 1 | 3.5–4.5 | human |
| Insulin Lispro
Protamine/Insulin Lispro |
Humalog Mix 75/25³ | Rx | Lilly | SC | ≤0.25 | 0.5–1.5 | 24 | human |
| Humalog Mix 50/50³ | Rx | Lilly | SC | ≤0.25 | 1 | 16 | human | |
| Insulin Injection
Regular (R) |
Humulin R U-100¹ | OTC | Lilly | SC, IM, IV*** | 0.5 | 2–4 | 6–8 | human |
| Humulin R U-500¹ | Rx | Lilly | SC | 0.5 | 1.75–4 | 24 | human | |
| Novolin R² | OTC | Novo Nordisk | SC, IM, IV | 0.5 | 2.5–5 | 8 | human | |
| Insulin Isophane
Suspension (NPH)/ Regular Insulin (R) |
Humulin 70/30¹ | OTC | Lilly | SC | 0.5 | 2–12 | 24 | human |
| Novolin 70/30² | OTC | Novo Nordisk | SC | 0.5 | 2–12 | 24 | human | |
| Insulin Isophane
Suspension (NPH) |
Humulin N¹ | OTC | Lilly | SC | 1–2 | 6–12 | 18–24 | human |
| Novolin N² | OTC | Novo Nordisk | SC | 1.5 | 4–12 | 24 | human | |
| NOTES | ||||||||
|
CSII = continuous subcutaneous insulin infusion, IM = intramuscular injection, IV = intravenous infusion, SC = subcutaneous injection *Onset for injectable formulations is always for the SC route. All times are approximate. **Maximum effect occurs between these times; actual effect may last longer. ***IV to be used in a clinical setting under proper medical supervision. Injectable insulins listed are available in a concentration of 100Units/mL; Humulin R, in a concentration of 500Units/mL for SC injection only, is available by prescription from Lilly for insulin resistant patients who are hospitalized or under close medical supervision. ¹Recombinant (using E. coli). ²Recombinant (using S. cerevisiae). ³Recombinant human insulin analogue (using E. coli). (Rev. 11/2012) |
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