Infectious Diseases

CDC: Update on Influenza Activity in the U.S.

December 08, 2017

Influenza activity was low during October 2017, has been increasing since the start of November

Antiretroviral Combination Linked to Increased CKD Risk

By December 08, 2017

The risk of chronic kidney disease (CKD) may be increased in patients living with HIV receiving tenofovir (TDF) with a ritonavir-boosted protease inhibitor compared to those who receive TDF with a non-nucleosidic reverse transcriptase inhibitor (NNRTI)

Sanofi Discontinues <i>C. Difficile</i> Tx Development

By December 08, 2017

Data that has been collected from the trial so far will be analyzed and shared with the scientific community in due time.

Newly Approved Prophylaxis Assessed in CMS-Seropositive Transplant Recipients

December 08, 2017

The researchers found that among 495 patients with undetectable CMV DNA at randomization, fewer patients in the letermovir group had clinically significant CMV infection or were classified as having a primary end point event by week 24 after transplantation, compared with the placebo group.

Antiretroviral Contraindications and Drug Interactions

December 06, 2017

A list of contraindications and drug interactions for HIV medications.

Community Acquired Pneumonia Guidelines

December 05, 2017

Diagnose, treat, and prevent community acquired pneumonia using key recommendations from the IDSA/ATS CAP guidelines.

Cancer Drug Linked to Drastic Depletion of HIV Reservoirs

December 04, 2017

Case report describes smoker with HIV infection receiving nivolumab for non-small-cell lung cancer

Vaginal Infection Treatments

November 30, 2017

Oral and topical vaginal infection treatment options for vulvovaginal candidiasis and bacterial vaginosis.

New Guidelines Issued for Managing Chronic Pain in HIV Patients

By November 30, 2017

All PWLH should receive brief standardized screening for chronic pain. A biopsychosocial approach should be used; and appropriate monitoring should take place.

HIV Postexposure Prophylaxis Algorithm: Occupational Exposure

November 29, 2017

Criteria for recommending postexposure prophylaxis (PEP) to HIV following occupational exposure

HIV Postexposure Prophylaxis Algorithm: Sexual Assault

November 29, 2017

Criteria for recommending postexposure prophylaxis (PEP) to HIV following sexual assault

CDC: 7-Month Improvement in Time From HIV Infection to Diagnosis

November 29, 2017

Increase in percentage of people at increased risk for HIV who reported getting an HIV test in past year.

Perrigo Approved for Generic Mycolog II Cream

By November 28, 2017

Triamcinolone acetonide is mainly effective because of its anti-inflammatory, antipruritic and vasoconstrictive actions.

Can Co-Testing Support Longer Cervical Cancer Screening Intervals?

November 28, 2017

Regardless of the cytology result, 5-year ≥CIN3 risks for an HPV-negative co-test nearly matched the performance of a negative co-test for each successive round of screening (0.114, 0.061, and 0041%, respectively).

Accuracy of Clinician Suspicion Tested Regarding Lyme Disease

November 27, 2017

Twelve percent of the 554 children who the treating clinicians thought were unlikely to have Lyme disease had Lyme disease, and 31% of those who the treating clinicians thought were very likely to have Lyme disease did not have Lyme disease.

Impact of MenACWY Vaccine Program on Disease Incidence Examined

By November 27, 2017

Reductions in incidence suggest an impact of the MenACWY vaccine program in this age group.

CDC: Raw Milk May Be Contaminated With Rare, But Serious Bacteria

November 22, 2017

Case of New Jersey woman becoming ill after drinking raw milk from Udder Milk company

First Complete 2-Drug HIV Regimen Gets FDA Approval

By November 21, 2017

Juluca combines dolutegravir, an HIV-1 integrase strand transfer inhibitor (INSTI), and rilpivirine, a non-nucleoside reverse transcriptase inhibitor.

ACP/CDC: Best Practice Advice for Hepatitis B Vaccination, Screening

November 21, 2017

All unvaccinated adults at risk for infection should be vaccinated; screening recommended for at-risk

Antiviral Prescribing for Flu Examined Among High-Risk Patients

By November 20, 2017

The investigators determined that empiric treatment of 4 patients with acute respiratory illness who were considered high-risk was needed to treat 1 with positive influenza laboratory tests.

Antifungal Tablets to Be Discontinued

By November 15, 2017

Novartis Pharmaceuticals has made a business decision to permanently discontinue the product Lamisil Tablets 250mg.

Early cART, Viral Suppression May Minimize Brain Injury in HIV Patients

November 15, 2017

No significant neuropsychological decline during two-year period with combination antiretroviral therapy

Antibiotic Combo for Cesarean Prophylaxis Linked to Better Maternal Outcomes

November 14, 2017

Improved maternal outcomes when azithromycin is added to cephalosporin for infection prophylaxis

Labeling for Several HCV Drugs Updated With New Drug Interactions

By November 13, 2017

The Food and Drug Administration (FDA) has approved updated labeling for several hepatitis C virus (HCV) infection treatments.

In ART-Treated HIV Patients With GI Discomfort, Consider EPI Assessment

By November 13, 2017

Of 100 participants, 32% had EPI (faecal elastase-1 <200 μg/g) and 20% severe EPI (faecal elastase-1 <100 μg/g).

New Vaccine for Hepatitis B Gets FDA Approval

By November 10, 2017

Two-dose vaccine for the prevention of hepatitis B in adults.

NSAID Compared to Antibiotic for Symptomatic Treatment of UTI

By November 09, 2017

The primary endpoint of symptom resolution at day 3 was met by 54% (72/133) in the diclofenac group vs. 80% (96/120) in the norfloxacin group (risk difference 27%, 95% CI 15% to 38%, P=0.98 for non-inferiority, P<0.001 for superiority).

Prevymis Approved for Prevention of Cytomegalovirus Infection and Disease

By November 09, 2017

Prevymis, a non-nucleoside CMV inhibitor (3,4 dihydro-quinazoline), inhibits viral replication through targeting the viral terminase complex.

Previous West Nile Infection Linked to Neurologic Abnormalities

November 09, 2017

Data were included for 262 patients with a history of WNV enrolled in a longitudinal cohort from 2002 to 2012; 117 patients underwent neurologic and neurocognitive evaluations.

Direct-Acting Antivirals Beneficial for HCV/HIV Co-Infected Patients

By November 07, 2017

The authors write, "the advent of direct acting antiviral (DAA) agent therapies has resulted in significant improvements in treatment rates for those with co-infection."