Infectious Diseases

Novel Antiviral Pimodivir Evaluated in Patients With Acute Uncomplicated Influenza A

By November 16, 2018

To evaluate the safety and antiviral activity of the treatment, patients in the TOPAZ trial (N=292) were randomized to receive pimodivir 300mg or 600mg, pimodivir 600mg plus oseltamivir 75mg, or placebo twice daily for 5 days.

Benefits of Simplified HCV Treatment Program Investigated

By November 16, 2018

The study, which was an open multi-cohort Markov model, aimed to analyze the clinical and economic outcomes of the United States HCV population from 2018 on.

HCV Treatment Linked to Reduced Risk of Incident CVD Events

By November 15, 2018

ERCHIVES (Electronically Retrieved Cohort of HCV Infected Veterans) was utilized to identify all patients who received HCV treatment for at least 7 weeks as well as a propensity-score matched group who did not receive treatment.

Hepatocellular Carcinoma Risk Following Antiviral Therapy for HCV Examined

By November 15, 2018

The retrospective study aimed to determine the risk of incident, or de novo, HCC following different regimens of antiviral therapy.

CDC: Record Number of Tickborne Disease Cases in US Last Year

November 15, 2018

There were 36,000 cases of Lyme disease in 2016, NBC News reported. Other tickborne disease cases in 2017 included: ehrlichiosis (7718), Rocky Mountain spotted fever (6248), babesiosis (2368), tularemia (239), and Powassan virus (33), according to the CDC.

Does Obesity Impact Virological Response in HCV Patients on DAA Therapy?

By November 14, 2018

The review analyzed 168 patients treated with an oral DAA at a single center from 2015 to 2017.

Direct-Acting Antiviral Therapy Uptake Examined Among HCV Patients

By November 14, 2018

The study utilized data from the Chronic Hepatitis Cohort Study, an observational cohort study, to assess demographic and clinical characteristics associated with DAA use.

Glecaprevir/Pibrentasvir 8-Week Regimen Evaluated in Treatment-Naïve HCV Patients With Compensated Cirrhosis

By November 14, 2018

In EXPEDITION-8, 280 treatment-naïve HCV patients (genotypes 1, 2, 4, 5, and 6) with compensated cirrhosis were treated with Mavyret for 8-weeks; the primary efficacy measure was SVR12 rate.

Ebola Outbreak Worst in Congo's History

November 14, 2018

"No other epidemic in the world has been as complex as the one we are currently experiencing," said Oly Ilunga Kalenga, MD, the Democratic Republic of the Congo's Minister of Public Health.

Direct-Acting Antiviral Therapy Linked to Reduced Risk of Incident T2D in HCV Patients

By November 13, 2018

The study compared US administrative claims data of HCV patients with ≥12 weeks of dispensed DAA therapy (N=17,848) to untreated HCV patients with follow-up data (N=108,350).

DAA Treatment and Hepatic Fibrosis Improvement in HCV: What's the Link?

By November 13, 2018

The study aimed to determine whether direct-acting antiviral therapy reduced fibrosis and assessed whether any predictors of treatment failure existed at 1-year follow-up.

Fluoxetine Evaluated as Treatment for EV-D68 Acute Flaccid Myelitis

November 13, 2018

In a propensity-adjusted analysis, there was a 0.2 decrease and a 2.5 increase in SLSS from initial examination to latest follow-up for fluoxetine-treated and untreated patients, respectively (P=.015).

Quick New Ebola Test Approved by FDA

November 12, 2018

The emergency use authorization is for the DPP Ebola Antigen System. It analyzes blood samples from people who have signs and symptoms of Ebola in addition to other risk factors.

New Antibiotic Shows Promise as Potential Treatment for Uncomplicated Gonorrhea

By November 09, 2018

Unlike other antibiotics used to treat gonorrhea, zoliflodacin, a spiropyrimidinetrione antimicrobial agent, works by inhibiting DNA biosynthesis by arresting the cleaved covalent gyrase complex, thereby impeding bacterial growth.

Progress Toward Goals in Global Health Is Slowing

November 09, 2018

The researchers found there have been global successes in mortality, such as the large decline for under-5s, but other mortality patterns show cause for concern.

Influenza Infection Increases Mortality Risk in Acute Myocardial Infarction

November 09, 2018

Investigators examined whether influenza is an independent risk factor for the development of acute myocardial infarction.

HBV Treatment Evaluation, Initiation Rates Compared Among Various Practice Settings

By November 08, 2018

The aim of the study was to assess both treatment evaluation as well as treatment initiation rates from various practice settings between January 2002 and December 2016.

Possible <i>Salmonella</i> Prompts Duncan Hines Cake Mix Recall

November 08, 2018

US health officials are investigating a Salmonella outbreak in which 5 people have become ill. Some said they ate a cake mix before becoming ill, and some may have eaten raw batter.

Hypoglycemia Following Antifungal Tx in Patient With Type 1 Diabetes

By November 07, 2018

"This is the first report of decreased insulin requirements in a patient with T1DM correlating with micafungin administration," noted the authors.

After 2007 Heart Association Recs, Increase Seen in Infective Endocarditis

November 07, 2018

Following the 2007 American Heart Association (AHA) update of recommendations for antibiotic prophylaxis (AP) to prevent infective endocarditis (IE), there has been a decrease in AP and an increase in IE incidence for high-risk individuals.

Cases of Polio-Like Illness Still Increasing in the US

November 07, 2018

There have been 219 possible cases of acute flaccid myelitis (AFM) reported in 25 states, and 80 of those cases have been confirmed, according to the latest update from the US Centers for Disease Control and Prevention. There were 120 confirmed cases in 2014, 22 in 2015, 149 in 2016, and 33 in 2017.

CDC Director Says Congo Ebola Outbreak May Be Uncontainable

November 07, 2018

No previous outbreak has resulted in the persistent presence of the disease.

Stratifying by Severity May Allow Shorter TB Tx Regimens

November 06, 2018

The researchers found that a baseline smear grade of 3+ relative to <2+, HIV seropositivity and adherence of ≤90% were significant risk factors for an unfavorable outcome

New Single-Vial Formulation of Egrifta Approved to Treat Excess HIV-Related VAT

By November 06, 2018

The new "F4" formulation is 4 times more concentrated than the version currently available on the market.

First-Of-Its-Kind Surgery Restores Boy's Ability to Walk Post-Acute Flaccid Myelitis

November 06, 2018

Nearly 400 people in the United States have been diagnosed since 2014, according to the US Centers for Disease Control and Prevention. So far this year, there have been 72 confirmed cases in 24 states.

Labeling for Two HIV Drugs Updated With Safety, PK Data for Pregnant Patients

By November 05, 2018

The "8.1 Pregnancy" and "12.3 Pharmacokinetics" sections have been updated with data showing no increase in the risk of overall major birth defects with 1st trimester exposure for rilpivirine.

Parents Frequently Save Leftover Antibiotics

November 02, 2018

"We found one of the common [reasons] parents gave for diverting antibiotics was that they wanted to avoid the costs involved with a second trip to the doctor," a coauthor said in a statement. "Follow-up surveys could examine whether there is a correlation between lack of access to health insurance or primary care and antibiotic diversion."

More Child Deaths Linked to Adenovirus Outbreak at NJ Facility

November 02, 2018

"It can be difficult to impossible to know how the virus got to the facility, what its source was, or what its specific mechanism of spread is from person to person," said New Jersey Department of Health Commissioner Shereef Elnahal, MD, CNN reported.

Contepo NDA Submitted for Treatment of Complicated UTI

By November 01, 2018

Contepo, an investigational epoxide intravenous (IV) antibiotic, has broad spectrum activity against Gram-negative and Gram-positive pathogens, including multi-drug resistant strains such as ESBL-producing Enterobacteriaceae.

Dengue Vaccine Candidate Gets FDA's Priority Review

By October 31, 2018

Two Phase 3 trials conducted in Asia and Latin America assessed the efficacy of the vaccine in >35,000 individuals aged 2 to 16 years.