Infectious Diseases

<i>C. difficile</i> Tied to Increased Graft Loss in Solid Organ Recipients

August 13, 2018

"These data support the importance of restrictive antibiotic use in the prevention of CDI and underscores the need for close surveillance of graft function in SOT recipients developing CDI," the authors write.

Arakoda Approved for the Prevention of Malaria

By August 10, 2018

The approval of Arakoda was based on over 21 trials involving over 3100 patients.

Cytovene-IV Labeling Updated to Include Additional Fertility Impairment Data

By August 10, 2018

Cytovene-IV is a deoxynucleoside analogue cytomegalovirus (CMV) DNA polymerase inhibitor.

Mavyret Labeling Updated With Dosing for Liver, Kidney Transplant Patients

By August 10, 2018

The Dosage and Administration section has been revised to state that Mavyret is recommended for 12 weeks in liver or kidney transplant recipients.

Omadacycline Gets FDA Committee Nod for Skin Infections, Pneumonia

By August 09, 2018

The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

FDA Panel Votes on Therapy for Nontuberculous Mycobacterial Lung Disease

By August 09, 2018

The recommendation was supported by materials developed from the ALIS New Drug Application (NDA), which included data from the CONVERT study.

New Tick Species Spreading in the United States

August 09, 2018

The ticks can reproduce rapidly and suck so much blood from a young animal that it dies, The Times reported.

Antiretroviral Formulations

August 07, 2018

A comparative list of antiretroviral drug formulations by class (NNRTIs, NRTIs, protease inhibitors, entry/fusion inhibitors, integrase inhibitors, PK enhancer, fixed-dose combination) for HIV-1 infection.

Antiretroviral Contraindications and Drug Interactions

August 07, 2018

A list of contraindications and drug interactions for HIV medications.

Antiretroviral Treatments

August 07, 2018

A list of treatment options for HIV infection.

Rifampin Effective for Latent Tuberculosis in Children

August 07, 2018

Rifampin has advantage of being a shorter, single-drug regimen that is palatable for children

Good Outcomes for HCV-Negative Recipients of HCV Kidneys

August 07, 2018

"In summary, this trial provides reassuring (albeit preliminary) evidence that kidneys from HCV-infected donors may be safely transplanted into HCV-negative recipients," the authors write.

Ciprofloxacin May Up Likelihood of Aortic Dissection, Rupture

August 06, 2018

Increased susceptibility observed in mouse model of sporadic aortic aneurysm and dissection

Some Bacteria Now More Tolerant of Alcohol-Based Sanitizers

August 06, 2018

Enterococci bacteria surviving exposure for longer periods of time

Rifampin Similar to Isoniazid for Preventing Active Tuberculosis

August 03, 2018

The rifampin regimen was not superior to the isoniazid regimen, as the upper boundaries of the 95% confidence interval for the rate differences of the confirmed cases and for the confirmed or clinically diagnosed cases of tuberculosis were less than the prespecified non-inferiority margin of 0.75 percentage points in cumulative incidence.

Dog's Saliva Caused Bacterial Infection Leading to Amputations

August 03, 2018

Doctors diagnosed Manteufel with a rare blood infection caused by Capnocytophaga canimorsus, which is commonly found in the saliva of most healthy dogs and is usually not harmful to humans, the Post reported.

Protease Inhibitors May Worsen Outcomes in Patients With HIV + Heart Failure

August 02, 2018

The researchers found that patients who were receiving a PI had higher rates of hyperlipidemia, diabetes mellitus, and coronary artery disease.

Evidence Exists for Persistence, Transmission of Ebola Virus

August 02, 2018

"These findings underscore the need for focused prevention efforts among survivors and sustained capacity to rapidly detect and respond to new Ebola virus disease cases to prevent recurrence of a widespread outbreak," the authors write.

FDA Committee Votes in Favor of New Malaria Prevention Treatment

By July 27, 2018

In clinical trials, tafenoquine, an 8-aminoquinoline, demonstrated efficacy against 2 primary types of malaria, Plasmodium vivax and P. falciparum malaria.

Canada Updates Guidelines for Hepatitis C Virus Infection

July 27, 2018

The Canadian Association for the Study of the Liver recommends birth cohort screening for individuals born from 1945 to 1975; a pretreatment evaluation of infected patients that includes clinical evaluation, viral load, genotype, and a fibrosis stage assessment.

CDC: <i>Salmonella</i>-Tainted Melon Outbreak Appears to Be Over

July 27, 2018

No deaths have been reported. Illnesses have been reported in Arkansas (1), Florida (1), Illinois (7), Indiana (14), Kentucky (1), Michigan (39), Missouri (11), Ohio (2), and Tennessee (1).

Could Zika Virus Be a Potential Treatment for Neuroblastoma?

By July 26, 2018

Even with intensive therapy, survival among neuroblastoma patients is poor, indicating a need for alternative treatments.

Guidance Provided for Reporting Foodborne Illness

July 26, 2018

These conditions are updated annually by the Council for State and Territorial Epidemiologists, with recommendations from the CDC. Often, until laboratory tests are completed, diagnoses remain unconfirmed.

WHO Targets for Chronic Hepatitis B Will Be Cost-Effective

July 26, 2018

The authors note that in order to reach the targets by 2030, approximately 14.5 million adults in at-risk populations would need to be screened to diagnose an estimated 870,000 undiagnosed cases.

WHO: Congo Ebola Outbreak Over

July 26, 2018

The last known Ebola case in Congo was in early June, but the WHO had to wait 42 days before declaring the outbreak officially over.

Novel Hepatitis B Virus Treatment Gets FDA's Fast Track Designation

By July 25, 2018

ABI-H0731 is an oral core protein allosteric modifier (CpAM) with selective and potent activity against all major HBV genotypes.

Juluca Maintains Viral Suppression in HIV Patients Through 100 Weeks

By July 25, 2018

The SWORD 1 and SWORD 2 trials enrolled 1027 HIV-infected and virologically suppressed adults; both trials had an early (Day 1 to Week 52) and late (Week 52 to Week 148) switch phase.

FDA Clears Smartphone-Enabled Urinalysis Kit for Home Use

By July 25, 2018

The kit works in tandem with existing smartphone cameras and a dedicated app.

Guidelines for ART Updated for Those With or at Risk for HIV

July 25, 2018

For initial therapy, an integrase strand transfer inhibitor plus 2 nucleoside reverse transcriptase inhibitors is generally recommended; the treatment choice should be guided by unique patient circumstances.

Increased Use of Truvada for PrEP Linked to Declines in New HIV Cases

By July 24, 2018

Findings from the study were presented at the 22nd International AIDS Conference (AIDS 2018) in Amsterdam.