Infectious Diseases

Odefsey Labeling Updated with New Data, Monitoring Recommendations

By August 22, 2017

In addition, the labeling includes information regarding renal laboratory tests and serum lipid changes in patients involved in these two trials.

Maraviroc HIV PrEP Regimens Assessed for Safety, Tolerability

August 22, 2017

"Maraviroc-containing PrEP regimens were safe and well tolerated compared with TDF-FTC in U.S. women," the authors write. "Maraviroc-containing PrEP for women may warrant further study."

Zika Infection, Semen May Interact Differently Than Previously Thought

August 21, 2017

"These data suggest that not all men who are symptomatically infected with Zika virus will have Zika virus RNA detectable in semen," the authors write.

Genvoya Labeling Updated with Interaction, Long-Term Study Data

By August 16, 2017

Under drug interactions, new clinical comments regarding concomitant systemic/inhaled/nasal/ophthalmic corticosteroids have been added.

Study Reveals Diverse Neurologic Complications with Zika Virus

August 15, 2017

Forty patients were enrolled, including 29 with Guillain-Barré syndrome (GBS), 7 with encephalitis, 3 with transverse myelitis, and 1 with newly diagnosed chronic inflammatory demyelinating polyneuropathy. Diverse Spectrum of Neurologic Syndromes Seen With Zika

Celiac Disease Linked to Increased Risk of Pneumococcal Infection

By August 15, 2017

After adjusting for socioeconomic index, diabetes, level of education, sex and age, an increased risk of pneumococcal infection among celiac disease patients was noted.

Fixed-Dose, Single-Tablet HIV Regimen Granted Priority Review

By August 14, 2017

The investigational fixed-dose treatment combines bictegravir (BIC) 50mg, a novel integrase strand transfer inhibitor (INSTI), with emtricitabine (FTC) 200mg and tenofovir alafenamide (TAF) 25mg, a dual-NRTI backbone.

Efficacy of Killed Whole-Cell Oral Cholera Vaccine Examined

August 14, 2017

During the 2 years after vaccination the 2-dose efficacy estimates were similar, with estimates of 56 and 59% in the first and second year, respectively.

Regeneron to Discontinue Development of RSV Treatment

By August 14, 2017

The primary endpoint of RSV prevention - assessed through day 150 of treatment - was not significantly reached.

HIV Viral Load Rebound Observed After Suppression in Pregnancy

August 14, 2017

The researchers found that 318 of the 470 women in the database met inclusion criteria. Nineteen women (6%) had viral load rebound with a mean log10 viral load near delivery of 2.71 copies/mL (=513 copies/mL), while 6 women (32%) had a viral load above 1,000 copies/mL.

NDA Submitted for Non-Cystic Fibrosis Bronchiectasis Treatment

By August 11, 2017

Linhaliq (previously known as 'Pulmaquin') consists of a mixture of liposome encapsulated and unencapsulated ciprofloxacin. Linhaliq has previously been granted Orphan Drug status for the management of bronchiectasis.

Gastroenteritis Hospitalizations Down with Rotavirus Vaccine Introduction

August 11, 2017

The researchers found that 16% of the 1,253,951 AGE-related hospitalizations among children aged <5 years were coded as a rotavirus-related hospitalization.

Contraindication Added to OCs, Other Ethinyl Estradiol-Containing Drugs

By August 10, 2017

The concomitant use of HCV drug combinations containing ombitasvir, paritaprevir/ritonavir, with or without dasabuvir is contraindicated due to the potential for liver enzyme elevations.

Data Support ACIP Decision Not to Use Live Attenuated Flu Vaccine

August 10, 2017

The researchers found that 19% of the 6,879 eligible participants tested positive for influenza virus, predominantly for A(H1N1)pdm09 and influenza B (11 and 7%, respectively).

FDA Approves Concomitant Administration of Zostavax and Flu Vaccines

By August 09, 2017

Zostavax is a vaccine indicated for the prevention of herpes zoster (shingles) in adults aged ≥50 years.

Cases of Cyclosporiasis on the Rise, CDC Warns

By August 08, 2017

A total of 206 cases of Cyclospora infections have been reported to the CDC as of August 2, 2017 among individuals who became ill on or after May 1, 2017.

Preventive Treatments for Recurrent Cellulitis Investigated

August 07, 2017

"Larger, high-quality studies are warranted, including long-term follow-up and other prophylactic measures," the authors write.

APA: Aging HIV Patient Population Presents Care Challenge

August 07, 2017

In this population, the stigma due to age, sexual orientation, and other factors can lead to negative outcomes.

Neonate Antibody Response Examined After Maternal Flu Vaccination

August 04, 2017

The researchers found that, compared to the 50 women with no vaccination in the previous year, the 91 women vaccinated the prior year exhibited higher baseline antibody titers and/or seroprotection rates against all four influenza strains, after controlling for covariates.

FDA Approves Mavyret, a Pan-Genotypic Treatment for HCV

By August 03, 2017

Mavyret is a once-daily, ribavirin-free treatment that combines glecaprevir, an HCV NS3/4A protease inhibitor, and pibrentasvir, an HCV NS5A inhibitor.

Stool Softeners Recalled Due to Possible Contamination

By August 03, 2017

Rugby Laboratories announced a voluntary recall of all lots of Diocto Liquid and Diocto Syrup (docusate sodium solutions) due to a risk of contamination with Burkholderia cepacia.

Guaifenesin/Pseudoephedrine Intervention May Cut Antibiotic Rxs for Acute URTI

By August 03, 2017

Results found that at day 8 of the study, a significantly lower amount of patients receiving guaifenesin/pseudoephedrine desired antibiotics compared to placebo, 4.2% vs. 8.0%, respectively.

Epclusa Indication Expanded to Include HCV/HIV Co-Infected Patients

By August 02, 2017

The supplemental New Drug Application (sNDA) approval was based on data from the Phase 3 open-label, ASTRAL-5 study.

Publication of Drug Interaction Unlikely to Impact Prescribing Patterns

By August 02, 2017

The findings point to "minimal to no measurable effect" in lowering the concomitant use.

Study Examines Potential of Saliva in Transmitting Zika

August 02, 2017

Researchers conducted experiments with monkeys and concluded that casual saliva contact such as kissing or sharing eating utensils is not enough for Zika to move from one host to another.

Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition

By August 01, 2017

For this study, the researchers examined data from the LifeLink Database for cases with ICD-9-CM code for benign intracranial hypertension (BIH) as well as an MRI or CT scan and a lumbar puncture within 15 or 30 days of the BIH code.

Treatment Regimens for Latent Tuberculosis Infection Compared

August 01, 2017

Isoniazid, rifampicin monotherapy, combination therapies can prevent active TB in latent TB infection

Antiretroviral Contraindications and Drug Interactions

July 28, 2017

A list of contraindications and drug interactions for HIV medications.

Acute Otitis Media Treatments

July 28, 2017

Acute otitis media treatment chart including select antibiotics and recommended doses.

Septic Arthritis Outbreak Highlights Need for Better Infection Prevention in Outpatient Settings

By July 27, 2017

Recovered organisms included various Streptococcus, Actinomyces, Haemophilus, Neisseria species, among others; all of the pathogens isolated were oral flora. Two patients also exhibited Staphylococcus aureus bacteria in the blood.