Infectious Diseases

FDA: Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

By May 18, 2018

The Agency has received reports of serious neural tube birth defects involving the brain, spine, and spinal cord in babies born to women who received dolutegravir for HIV treatment.

Proportion of Drug-Intoxicated Organ Donors on the Rise in US

May 18, 2018

There was no significant difference in survival after transplantation for recipients of organs from donors who died from drug intoxication or blunt head injury; results were similar for comparisons involving other causes of death.

Truvada Approved for HIV-1 Pre-Exposure Prophylaxis in At-Risk Adolescents

By May 17, 2018

The use of Truvada for PrEP in the adolescent population was based on a single-arm, open-label clinical study (ATN113) among 67 HIV-1 negative young men (aged 15 to 17 years) who have sex with men (YMSM).

New Rabies Test Could Radically Change Testing, Treatment

May 17, 2018

LN34 doesn't require complex training. And it can produce reliable results whether the animal tissue probed is fresh, frozen, or decomposed, the researchers said.

Hepatitis C-Exposed Infants Not Adequately Screened

May 16, 2018

HCV-infected women were more likely to be <30 years of age (67 vs 53%), be white (93 vs 72%), be insured by Medicaid (77 vs 29%), and have opiate use disorder (68 vs 1%) compared with HCV-uninfected women.

IV Combo Antibiotic Recalled Due to Potential for Decreased Potency

By May 15, 2018

The 36 recalled lots were manufactured by Hospira and marketed by Apotex.

HPV Vaccination May Offer Protection Against Cervical Precancer

By May 11, 2018

The authors concluded, "There is high-certainty evidence that HPV vaccines protect against cervical precancer in adolescent girls and young women aged 15 to 26," while also indicated that future studies should have long-term follow-up.

<i>B. cepacia</i> Outbreak Tied to No-Rinse Cleansing Foam

By May 11, 2018

As a result of the tests, the FDA is advising consumers and clinicians to avoid using all lots of Remedy Essentials No-Rinse Cleansing Foam.

Cancer Incidences and Burden Expected to Shift in HIV-Positive

May 08, 2018

The estimated total cancer burden in PLWH will decrease from 8,150 cases in 2010 to 6,690 cases in 2030, with prostate and lung cancer projected to be the most common cancer types.

Eyes of Ebola Survivors Show Localized Pathological Changes

May 07, 2018

All lesions respected the horizontal raphe, and the fovea was spared. A V-shaped hyperreflectivity of the outer nuclear layer was seen with OCT imaging, overlying discontinuities of the ellipsoid zone and interdigitation zone in smaller lesions.

Antiretroviral Treatments

May 07, 2018

A list of treatment options for HIV infection.

Antiretroviral Contraindications and Drug Interactions

May 07, 2018

A list of contraindications and drug interactions for HIV medications.

Vaccine for Chikungunya Prevention Gets Fast Track Designation

By May 04, 2018

There are currently no approved treatments or vaccines available for chikungunya, a virus transmitted through mosquito bites.

Drug-Induced Chemical Sensitivity After Exposure to Azole Antifungals

By May 04, 2018

His reactions were also triggered by foods such as bananas, apples, and milk.

FDA Panel Votes on Plazomicin for Complicated UTI, Bloodstream Infections

By May 03, 2018

The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.

HBV Reactivation Examined in Patients Treated With TNF Antagonists

By May 03, 2018

The authors examined data from 8887 individuals who began TNF antagonist treatment for an autoimmune disease from 2001 through 2010 and were followed through 2012; 52% of these patients were screened for HBV before treatment.

Screening insufficient for newborns exposed to hepatitis C virus

May 02, 2018

In this retrospective study, only a fraction of infants receiving well-child care at the study institution were screened for hepatitis C, despite being born to mothers with a known history of hepatitis C virus infection.

Vectorborne Diseases Up More Than Two-Fold From 2004 to 2016

May 02, 2018

During 2004 to 2016, 82 percent of all tickborne disease reports were Lyme disease

First-in-Class Antifungal Fast-Tracked for Vulvovaginal Candidiasis

By May 01, 2018

SCY-078 is an investigational antifungal agent that is a semi-synthetic derivative of the natural product enfumafungin.

In-utero exposure to tenofovir-emtricitabine not associated with higher risk of adverse birth outcomes

May 01, 2018

Pairwise comparisons of tenofovir-emtricitabine and ritonavir-boosted lopinavir (TDF-FTC-LPV/r), zidovudine-lamivudine and ritonavir-boosted lopinavir (ZDV-3TC-LPV/r), and tenofovir-emtricitabine and ritonavir-boosted atazanavir (TDF-FTC-ATV/r) HIV regimens among pregnant women with HIV showed all three regimens had comparable risks of preterm birth, low birth weight, and neonatal death.

Flu Vaccines Have High Impact, Even With Relatively Low Efficacy

May 01, 2018

The researchers found that even relatively low-efficacy influenza vaccines can have a high impact, especially with optimal distribution across age groups. In order to minimize mortality and DALYs, the optimal distribution of the vaccine uptake shifts toward the elderly as vaccine efficacy declines.

Novel Antiretroviral Therapy Trogarzo Now Available to Treat HIV-1

By April 30, 2018

The approval of Trogarzo was supported by a clinical trial (N=40) of heavily treatment-experienced adults with multidrug resistant HIV-1 infection who continued to have high levels of HIV RNA in their blood despite antiretroviral therapy.

Antiretroviral Formulations

April 30, 2018

A comparative list of antiretroviral drug formulations by class (NNRTIs, NRTIs, protease inhibitors, entry/fusion inhibitors, integrase inhibitors, PK enhancer, fixed-dose combination) for HIV-1 infection.

PrEP Eligibility Based on HIV Status

April 27, 2018

Determine HIV status and patient's eligibility for PrEP using this flowchart.

HIV Risk Behavior Assessment

April 27, 2018

Criteria to assess HIV risk behavior in men who have sex with men (MSM), heterosexually active men and women, and injection drug users.

FDA to Review Fluzone Quadrivalent 0.5mL Dose for Younger Patients

By April 27, 2018

The sBLA included clinical data from a Phase 4 study that enrolled nearly 2000 children and assessed the safety and immunogenicity of the 0.5mL dose.

Drug-Related Endocarditis Cases Up From 2007 to 2015

April 27, 2018

Most cases were insured by federal and/or state programs (73.6 and 10.1%, respectively), but many (44.9%) patients were considered under-insured. In 2015, hospital charges of $4,580,786.88 were identified for the 66 cases of illicit drug-associated endocarditis.

Risk of Adverse Birth Outcomes No Higher With TDF-FTC-LPV/r

April 26, 2018

The researchers compared the risks of adverse birth outcomes among infants with in utero exposure to the 3 regimens, using data from two U.S.-based cohort studies.

HIV Pre-Exposure Prophylaxis Algorithm: Men Who Have Sex With Men

April 25, 2018

CDC interim guidance on HIV pre-exposure prophylaxis for men who have sex with men.

Antifungal Formulations

April 24, 2018

List of different formulations (eg, tablets, capsules, liquids, topicals, injections, etc) available for the various prescription and over-the-counter antifungal therapies.