Infectious Disease

<i>C. Difficile</i> Risk Higher With Stoma Reversal vs Difficile

April 18, 2018

Factors associated with C. difficile infection incidence in the 30-day postoperative period after controlling for other variables include stoma reversal (odds ratio, 2.701; P<.001), smoking (odds ratio, 1.520; P<.022), steroids (odds ratio, 1.677; P<.048), and disseminated cancer.

Combo Antibiotic Gets Priority Review for New Pneumonia Indication

By October 13, 2017

Avycaz is a combination antibiotic consisting of ceftazidime, a cephalosporin, and avibactam, a beta-lactamase inhibitor.

Updated HCV Guidance Focuses on Additional Patient Populations

By October 03, 2017

The updates include a primer on HCV resistance and guidance on treating patients who have undergone kidney transplantation.

Prophylactic Antibiotic Course Post C-Section May Reduce SSI Rate

September 20, 2017

The researchers found that the overall rate of SSI was 10.9% in the cohort. Overall, 6.4 and 15.4% of women in the cephalexin-metronidazole and placebo groups, respectively, were diagnosed with SSI (relative risk, 0.41).

Adverse Birth Outcomes Examined by Antiretroviral Tx Regimens

By August 25, 2017

The study authors reported that of the 11,932 infants exposed to HIV, 5780 (48.4%) of them were considered ART exposed from conception.

CVD Risk Significantly Heightened in Years Follow Severe Infection

August 09, 2017

While the first year after infection has the highest risk (adjusted hazard ratio [aHR], 6.33), an increased risk persists for the second (aHR, 2.47) and third year (aHR, 2.12) after infection.

Drug Tampering by Healthcare Worker Causes Outbreak at Hospital

By July 07, 2017

The investigation found that that the nurse had replaced the active medication with saline or another solution. All of the patients recovered except one who died from a sepsis infection.

Study Validates New HPV Vaccination Recommendations

May 25, 2017

Beyond the conclusion that 2 doses were just as protective as 3, the researchers found that both dose regimens offered much more protection against genital warts than a single dose or no vaccine at all.

An End to the U.S. HIV/AIDS Epidemic May Be In Sight

By May 15, 2017

By using the Centers for Disease Control and Prevention (CDC) HIV surveillance data, researchers were able to project yearly estimates of new infections and forecast the route of HIV in the U.S.

New Estimates of Life Expectancy for Young HIV Patients on ART

May 12, 2017

In fact, a 20-year-old with HIV who began antiretroviral treatment in 2008 or later and had a low viral load after a year of treatment has a life expectancy that's close to that of the general population.

Drug Interactions Updated for Two HIV Meds

By May 08, 2017

Alternative corticosteroids including beclomethasone and prednisolone should be considered, particularly for long-term use.

Internet Diagnosis Searches Eroding Trust in Physicians

May 08, 2017

Researchers presented 1,374 parents with a vignette of a child who'd had a rash and worsening fever for 3 days.

For HIV Patients with Dyslipidemia, Pitavastatin Superior to Pravastatin

By April 19, 2017

The analysis found treatment with Livalo led to a statistically significant and superior reduction in LDL-C vs. pravastatin at Week 12.

Certain Antidiabetic Agents Linked to Increased Pneumonia Risk

By April 17, 2017

Results showed that compared with current use of metformin + sulfonylurea, the use of thiazolidinediones + metformin was associated with an increased risk of CAP.

AAP: New Bacteremia Guidelines Needed for Febrile Outpatient Toddlers

March 13, 2017

As pneumococcal rates dropped, rates of E. coli, Salmonella spp, Staphylococcus aureus increased

Fatal Infection Linked to Medical Marijuana

February 16, 2017

Researchers had DNA analysis conducted to identify the fungi and bacteria contained in the samples.

HIV Monoclonal Antibody Effective in Patients with Multidrug Resistant Infection

By February 15, 2017

Results were in line with previous studies which showed an patients achieving a mean reduction in viral load of 1.6 log10 over a 24 week treatment period.

FDA: Warning Added to HCV Drug Class

By February 14, 2017

HBV reactivation is described as an abrupt rise in HBV replication manifesting as a rapid increase in serum HBV DNA level.

Two-Drug HIV Combo as Effective as Three-, Four-Drug Regimen in Phase 3 Studies

By February 14, 2017

Janssen announced positive data from the SWORD Clinical Trial Program of the two-drug regimen dolutegravir (ViiV Healthcare) and rilpivirine (Janssen) for the maintenance treatment of HIV-1 infection in patients who have already achieved viral suppression.

Plant Packs a Powerful Punch Against Superbugs

February 13, 2017

Could the extract from a berry common in Florida be the answer to antibiotic-resistant staph bacteria?

FDA Warns Against the Use of Drug Promoted as 'Cancer Cure'

By January 11, 2017

A laboratory analysis found the presence of Variovorax paradoxus.

Glecaprevir/Pibrentasvir NDA Submitted for Pan-Genotypic HCV

By December 19, 2016

AbbVie announced the submission of a New Drug Application (NDA) for the pan-genotypic regimen of glecaprevir/pibrentasvir being developed for the treatment of chronic hepatitis C virus (HCV).

Flu Vaccination During Pregnancy 'Still Falls Short' of Recommendations

By December 08, 2016

Data from the Birth Defects Study found that influenza vaccination coverage rose during the 2012-13 and 2013-14 season from 35% to 41%, respectively.

CDC Announces 7 U.S. Public Health Priorities

By December 05, 2016

The Centers for Disease Control and Prevention (CDC) issued the final report on the Winnable Battles program which highlights public health priorities with large-scale impact on health and strategies that may help to address them.

Multiple Labeling Updates for HIV Drug Combo

By November 30, 2016

The Food and Drug Administration (FDA) has approved a supplemental New Drug Application (sNDA) for Kaletra (lopinavir/ritonavir; AbbVie) film-coated tablets and oral solution.

New Contraindications, Warnings Added to Ritonavir Labeling

By November 30, 2016

The Food and Drug Administration (FDA) has approved a supplemental New Drug Application (sNDA) for Norvir (ritonavir; AbbVie) 80mg/mL oral solution, 100mg tablets and 100mg soft-gel caps.

Certain Drug Classes Linked to More ED Visits for Adverse Drug Reactions

By November 22, 2016

A study published in JAMA reports that anticoagulants, antibiotics, diabetes drugs, and opioids are the most common drug classes related to emergency department visits for adverse drug events in the country.

FDA Expands Age Range for FluLaval Quadrivalent Vaccine

By November 21, 2016

GlaxoSmithKline announced that the Food and Drug Administration (FDA)'s Center for Biologics Evaluation and Research has approved an expanded indication for FluLaval Quadrivalent (influenza vaccine) to include the use in children aged ≥6 months.

Which Alzheimer's Drug Is Linked to the Highest Pneumonia Risk?

By November 21, 2016

Researchers aimed to compare the risk of pneumonia with the use of donepezil, oral rivastigmine, transdermal rivastigmine, galantamine, and memantine.

Study ID's Ocular Damage in Infants Related to Zika

November 14, 2016

For infants with congenital Zika syndrome (CZS), Zika virus (ZIKV) can cause retinal damage, which can be seen on optical coherence tomography (OCT), according to a study published online in JAMA Ophthalmology.