IDWEEK 2017

Do Posaconazole Tablets Carry Hypertension, Hypokalemia Risks?

October 11, 2017

Rebecca Wittenberg, PharmD, spoke to MPR at IDWEEK 2017 about the research paper she co-authored on posaconazole and hypertension, hypokalemia risks.

Are Statins Appropriately Utilized Among HIV Patients?

October 11, 2017

MPR spoke with Gerome Escota, MD, at IDWeek 2017, who co-authored a review at a large urban outpatient center to identify the proportion of appropriate statin use.

Does Abacavir Up the Risk for MI and CAD?

October 11, 2017

MPR caught up with Mark Shaefer, PharmD, at IDWEEK 2017 to speak about the research he led concerning abacavir use and myocardial infarction (MI) risks.

Safety of Single Dose IV Peramivir Examined in Pediatric Influenza

By October 08, 2017

Age-appropriate doses of IV peramivir were compared to five days of oral oseltamivir in patients aged 0-17 years.

High Completion Rate for Isoniazid-Rifapentine in Latent TB

By October 08, 2017

Effective treatment of latent tuberculosis infection is key to TB control efforts and approaching the goal of TB elimination, the authors reported.

High Cure Rates, Microbiologic Eradication With IV Fosfomycin

By October 08, 2017

Study patients were randomized to 1-hour IV fosfomycin 6g infusion every 8 hours (18 g total daily dose) or IV piperacillin/tazobactam 4.5g infused over 1 hour every 8 hours for a fixed 7 days.

Safety Profiles Similar for Delafloxacin, Vancomycin/Aztreonam for ABSSSI

By October 08, 2017

Researchers compared the integrated safety outcomes between delafloxacin and vancomycin/aztreonam from two Phase 3 ABSSSI studies.

For Latent TB, 3-Month Rifapentine + Isoniazid May Be Favorable for Some

By October 08, 2017

Clinical and demographic profiles of patients were compared on those who completed the 9H vs. 3HP regimens with a focus on adverse events, which can commonly cause treatment discontinuation.

No Statistical Difference for Doxycycline, Azithromycin in CAP Outcomes

By October 08, 2017

The ceftriaxone + doxycycline regimen has been favored in light of 'recent concerns of increased cardiovascular risk associated with azithromycin

ART Limits Appropriate Contraceptive Options for Women with HIV

By October 08, 2017

The researchers sought to determine the type and frequency of hormonal contraceptives and ART prescribed to women with HIV infection and prevalence of resulting drug to drug interaction potential.

Traditional, Alternative Combo ART Regimens Compared in Pregnant Women

By October 08, 2017

Traditional combination ART consists of 2 nucleoside reverse transcriptase inhibitors + 1 protease inhibitor; this prospective study of 274 pregnant women infected with HIV compared their viral load near delivery after receiving traditional cART.

Combo Treatment Assessed in Black Patients Co-Infected With HIV, HCV

By October 08, 2017

Retrospective chart reviews were conducted for Black, genotype 1 (GT1), HIV/HCV co-infected patients treated with ledipasvir/sofosbuvir (LDV/SOF) at 3 hospitals.

Stepdown Tx for Uncomplicated Gram-Negative BSI: Beta-Lactam vs. Fluoroquinolone

By October 08, 2017

The researchers compared the effectiveness of oral beta-lactams to fluoroquinolones in the treatment of Enterobacteriaceae bloodstream infections (EBSI) in adult patients.

Ceftaroline Fosamil vs. Vancomycin: Hospital Stay Compared in ABSSSI

By October 08, 2017

Intravenous (IV) antibiotics such as CPT is indicated for ABSSSIs "but real world clinical comparative data is limited."

Macrolide Prophylaxis Examined in HIV-Infected Patients

By October 07, 2017

Prophylaxis against mycobacterium avium-intracellulare complex (MAC) is recommended for patients with CD4 counts of 3.

AKI Frequency in Critically Ill Assessed for 2 Antibiotic Regimens

By October 07, 2017

The authors gathered clinical and demographic data from the University of Kentucky Center for Clinical and Translational Science Enterprise Data Trust, for adults who received TZP+VAN or CFP+VAN for ≥48 hours in the ICU.

Is Telavancin Effective in the Treatment of Bacteremia, Endocarditis?

By October 07, 2017

To investigate the efficacy of telavancin in the treatment of bacteremia and infective endocarditis, the authors looked at data from the Telavancin Observational Use Registry, which reports on outcomes of patients treated with telavancin in clinical practice.

Delafloxacin, Vancomcyin/Aztreonam Efficacy Similar in Gram-Negative ABSSSI

By October 07, 2017

A total of 1,042 patients with infection were randomly assigned to receive either intravenous/oral DLX monotherapy or VAN (15mg/kg) with AZ for 5 to 14 days.

Can Gender Affect ART Responses in HIV-1 Positive Individuals?

By October 07, 2017

The study authors sought to contribute to the evidence base on gender differences in virologic and immunologic responses to ART in treatment-naïve individuals.

Fosfomycin Inj Well-Tolerated in Complicated UTI, Acute Pyelonephritis

By October 07, 2017

Participants included 464 hospitalized adults with cUTI or AP diagnosis, randomly assigned to be administered either ZTI-01 or piperacillin/tazobactam for a fixed 7 days.

Antacids May Increase Some Children's Risk of <i>C. diff</i> Infection

By October 07, 2017

Whereas epidemiological risk factors for CDI among adults are well known, data is limited for children.

Omadacycline Non-Inferior to Linezolid in ABSSSI Patients With CKD

By October 07, 2017

Omadacycline is a novel, broad-spectrum aminomethylcycline related to tetracyclines; the OASIS phase 3 trial investigated whether it was non-inferior to linezolid.

Febrile Seizures Risk Compared With Inactivated Flu Vaccine, PCV13

By October 07, 2017

Researchers assessed the risk of febrile seizures following inactivated influenza vaccine and pneumococcal conjugate vaccine-13 during 2013-14 and 2014-15 flu seasons.

Viral Failure Rates for Dolutegravir-Based vs. Other Guideline Regimens

By October 07, 2017

Rates of viral failure were compared in HIV patients initiated on dolutegravir-based vs. other guideline recommended regimens in clinical care.

PCV13 and PPSV23 Administration: Does the Order Affect Immune Response?

By October 07, 2017

Two sequential administration groups were compared by demonstrating the antibody response curve and the reverse cumulative distribution curve analyses by serotype.

Efficacy of High- vs. Standard-Dose Flu Vaccine Compared in Older Adults

By October 07, 2017

For adults aged ≥65 years, seasonal flu epidemics pose significant disease burden annually and not many vaccines are specifically formulated for this patient population.

Long-Term Safety and Efficacy of TAF vs. TDF in Blacks and Non-Blacks

By October 07, 2017

At baseline, the viral load, CD4 cell counts, renal laboratory parameters, and bone mineral density (BMD) were comparable between the 2 treatment arms for blacks and non-blacks.

Zostavax Vaccine Efficacy: A 12-Year Review

By October 06, 2017

The researchers conducted the study because protection against herpes zoster has been "shown to wane with time" and effect sizes "can be imprecise".

Appropriateness of Dx, Antibiotic Use in Pediatric Uncomplicated UTIs

By October 06, 2017

Appropriate diagnosis was defined as confirmed UTI which included: pyuria, a positive urine culture, and lower urinary tract symptoms.

Early De-Escalation of Vancomycin + Pip/Tazo May Reduce AKI Risk

By October 06, 2017

Researchers sought to determine whether or not antimicrobial de-escalation significantly affects AKI rates.