Nasal povidone-iodine should be seen as an alternative to nasal mupirocin ointment to reduce risk of deep Staphylococcus aureus surgical site infections following arthroplasty and spine fusion surgery, according to a trial reported at IDWeek 2012.
A study presented at IDWeek 2012 of patients with mycobacterial infections treated with clofazimine under the FDA's Single Patient Investigational New Drug program found limited safety information, despite mandatory reporting requirements for the program.
Use of gentamicin-collagen sponges reduced risk of surgical site infections following cardiac procedures, according to a meta-analysis presented at IDWeek 2012.
A pre-admission protocol using cutaneous chlorhexidine gluconate cloths significantly reduced the incidence of surgical site infections vs in-hospital peri-operative skin preparation only, according to a study presented IDWeek 2012.
Oral delafloxacin is effective against ABECB and for community-acquired pneumonia, according to results of two double-blind randomized phase 2 trials presented at IDWeek2012.
Carbapenem-resistant gram-negative bactierial infections are strongly associated with previous antibiotic use and health care exposure, according to study results presented at IDWeek 2012.
A post-hoc analysis of data pooled from the largest multicenter, randomized, double-blinded, head-to-head clinical trials to date involving patients with Clostridium difficile-associated diarrhea treated with oral vancomycin and oral metronidazole presented at IDWeek 2012 has shown statistically superior clinical success with oral vancomycin.
Ceftolozane/tazobactam has greater in vitro activity than ceftazidime, cefepime, and piperacillin/tazobactam when tested against P. aeruginosa and Enterobacteriaceae strains that cause pneumonia in U.S. hospitals, as seen in a study presented at IDWeek 2012.
In critically ill adult patients, extended infusion of meropenem correlates with a faster progression to death vs. intermittent infusion of the drug, as reported at IDWeek 2012.
At IDWeek, studies showed ceftaroline plus avibactam has wide-ranging in vitro bactericidal activity against resistant acute bacterial skin and skin structure infections clinical isolates.