Hypotension

Orthostatic Hypotension Guidelines Called into Question

By July 31, 2017

After adjustments, measurement 1 was significantly associated with risk of fall (HR 1.22, 95% CI: 1.03-1.44), fracture (HR 1.16, 95% CI: 1.01-1.34), syncope (HR 1.40, 95% CI: 1.20-1.63), and death (HR 1.36, 95% CI: 1.23-1.51). Measurement 2 was associated with all long-term outcomes, including motor vehicle crashes (HR 1.43, 95% CI: 1.04-1.96).

Angiotensin II Treatment Examined in Vasodilatory Shock

May 24, 2017

Researchers randomized patients with vasodilatory shock receiving more than 0.2 µg of norepinephrine/kg body weight/minute or equivalent dose of another vasopressor to receive angiotensin II or placebo infusions.

Self-Administered Nasal Spray Examined for Paroxysmal SVT

May 15, 2017

The researchers found heart rate was controlled within 15 minutes in 87% of patients who received a 70-mg dose of the nasal spray; 75% of patients who got 105-mg; and 95% of patients given a 140-mg dose.

More Intensive Alveolar Strategy May Benefit Cardiac Sx Patients

March 23, 2017

The mean and median pulmonary complications score was 1.8 and 1.7, respectively, for the intensive recruitment strategy group, compared with 2.1 and 2.0, respectively, for the moderate strategy group.

Drug Shortage Linked to Increased Death in Patients with Septic Shock

By March 21, 2017

Higher rates of septic shock deaths occurred during quarters of norepinephrine shortage.

How Often is Orthostatic Hypotension a Risk Factor in Incident Falls?

March 21, 2017

The researchers observed an increased relative risk of UF with impaired orthostatic BP stabilization at 40 seconds after standing (OH[40]) (relative risk, 1.52).

Orthostatic Hypotension and Dementia: What's the Link?

March 13, 2017

Middle-aged adults found 40 percent more likely to develop dementia over time

Nipride RTU Approved for Immediate BP Reduction

By March 10, 2017

Nipride RTU is approved for immediate blood pressure reduction and also carries a Boxed Warning describing the possibility of excessive hypotension and cyanide toxicity.

Drug for Catecholamine Resistant Hypotension Shows Promise in Phase 3 Study

By February 27, 2017

La Jolla announced positive data from the ATHOS-3 study which evaluated LJPC-501 (angiotensin II) for the treatment of catecholamine resistant hypotension (CRH).

New Warning Added to Antipsychotic Drug Labeling

By February 27, 2017

The FDA has approved updates to all antipsychotic medication labels to specifically warn of somnolence, postural hypotension, and motor and sensory instability risks.

Hypotension Drug Gets FDA Approval

By February 01, 2017

The Food and Drug Administration (FDA) has approved Corphedra (ephedrine sulfate injection; Par) for the treatment of clinically important hypotension occurring in the setting of anesthesia.

Hormone ID'd as Link Between Bone and Vascular Disease

January 11, 2017

Significant association with carotid-femoral pulse wave velocity persists after multivariable adjustment

New Link Found Between Orthostatic Hypotension and Dementia

October 12, 2016

There is an association between orthostatic hypotension and an increased risk for dementia, according to a new study published online October 11 in PLOS Medicine.

Levosimendan Investigated in Patients with Septic Shock

October 07, 2016

Drug also tied to lower odds of successful weaning from mechanical ventilation in adults with sepsis

Orthostatic Hypotension Drug Updated with New Warnings

By October 05, 2016

Hypersensitivity reactions including anaphylaxis, angioedema, bronchospasm, urticaria and rash have been reported in postmarketing experience.

Sterility Concerns with Phenylephrine HCI Injection Prompt Recall

By September 01, 2016

Sandoz announced a voluntary recall of four lots of Phenylephrine HCI Injection, USP, 10mg/mL, 5mL and 10mL vials due to concerns of product sterility during an inspection at Allergy Laboratories, Inc.

Vasopressin: An Effective First-Line Option for Septic Shock?

By August 03, 2016

In adults with septic shock, early vasopressin use vs. norepinephrine did not improve the number of kidney failure-free days, a study in JAMA concluded.

Droxidopa Effective, Safe for Symptomatic NOH Across Age Groups

By April 20, 2016

Use of the norepinephrine oral prodrug, droxidopa, for the treatment of symptomatic neurogenic orthostatic hypotension is effective and "generally well tolerated across a range of ages," including in those 75 years and older.

A Dose of His Own Medicine Leaves Patient With a Bad Taste in His Mouth

By February 24, 2016

This is only the second reported case of these rare adverse events occurring with this cardiovascular agent.

Critical Care Drug Recalled After Discoloration Complaints

By January 04, 2016

PharMEDium Services, LLC announced a voluntary recall of 29 lots of 4mg Norepinephrine Bitartrate (16mcg/mL) added to 0.9% Sodium Chloride in 250mL Viaflex Bag and 3 lots of 8mg Norepinephrine Bitartrate (32mcg/mL) added to 0.9% Sodium Chloride in 250mL Viaflex Bag.

The Impact of Low Blood Sugar on the Heart

By November 04, 2015

In a new study published in Diabetes, researchers examined the effects of hypoglycemia on cardiovascular autonomic control and found that there is a clear change in the body's responses to cardiovascular stress.

Resting Heart Rate Linked to Risk of Violent Behavior

By September 09, 2015

An increased risk for violent criminality in males was seen in those with a low resting heart rate in late adolescence, an article published in JAMA has shown.

Time to Restarting BP Meds Post-Op Could Impact Outcomes

By June 04, 2015

Resuming treatment with angiotensin receptor blockers (ARBs) within two days following surgery is associated with reduced mortality rates in the first month post-surgery, reports a new study in the journal Anesthesiology.

Look-a-Like Injectables Prompt ASHP, ISMP to Issue National Alert

By March 24, 2015

The ASHP and ISMP have issued a National Alert for Serious Medications Errors regarding potentially dangerous mix-ups of neostigmine injection and phenylephrine injection.

FDA Approves First Vasopressin Injection

November 12, 2014

Par announced it has received approval from the Food and Drug Administration (FDA) for its New Drug Application for Vasostrict (vasopressin injection), the first vasopressin injection to be approved.

Weight-Loss Surgery May Raise Risk of Severe Headaches

October 23, 2014

But experts find the study too small, problem too rare to be of concern.

First Neurogenic Orthostatic Hypotension Drug Launched

September 02, 2014

Lundbeck announced the availability of Northera (droxidopa) capsules for the treatment of orthostatic dizziness and lightheadedness in adult patients with symptomatic neurogenic orthostatic hypotension (NOH).

Growing Uncertainty in BP Treatment Targets

August 04, 2014

A new study has found that blood pressure (BP) below and above the current Eighth Joint National Committee (JNC 8) recommended targets is linked to an increased risk of renal disease and mortality.

Contact-Free Vital Signs Monitoring Device Gets FDA Clearance

July 02, 2014

EarlySense has announced that the FDA has issued clearance for the Chair Sensor Solution, the first automatic contact-free sensor for continuous monitoring of patients' vital signs in a chair.

Rx Adherence Up for Hispanics Post-Medicare Part D Launch

June 04, 2014

Hispanics became much more likely to take their heart medicines after Medicare's prescription drug benefit plan was launched in 2006, but there was only a small increase seen among black patients.