Hyperlipoproteinemias

Statin Use May Protect Against Kidney Stone Formation

By February 09, 2018

For this study, researchers aimed to determine the impact of statin use on the risk of nephrolithiasis and to assess whether higher lipid levels were associated with the risk of stone formation.

Herb-Drug Interactions Can Lead to Severe Adverse Reactions

By January 24, 2018

For this review, researchers performed an extensive literature search for studies and cases where an adverse drug reaction occurred likely due to an interaction between an herbal and a prescribed medicine.

Heat Not Needed for Bikram Yoga to Confer Vascular Benefits

January 23, 2018

In both yoga groups there was an increase in brachial artery flow-mediated dilation (P<0.05). In the time-control group there were no significant changes in any outcome variables.

Prior Authorization Policies for PCSK9 Inhibitors Burdensome, Says Study

January 22, 2018

Diagnostic confirmation via genetic testing or meeting minimum clinical scores/criteria was required for patients with familial hypercholesterolemia.

Broader statin use more likely to prevent cardiovascular events

January 12, 2018

High levels of agreement between statin eligibility found between several guidelines included in this study

Can Coronary CTA Identify Future Major Adverse Cardiovascular Events?

January 11, 2018

The researchers found that the rate of MACE was higher with the presence of high-risk plaque (6.4 versus 2.4%; hazard ratio, 2.73).

Recall: Clopidogrel Bottles May Contain Simvastatin Tablets

By January 10, 2018

International Laboratories, LLC is notifying distributors and customers by letter and is arranging for return of all recalled products.

Using Statins to Prevent ASCVD: 5 Major Guidelines Compared

January 03, 2018

"Guidelines recommending that more persons use statins for primary prevention of ASCVD should prevent more events than guidelines recommending use by fewer persons," the authors write.

New Calculation Method Better at Estimating LDL-C in Patients Who Don't Fast

By January 02, 2018

esearchers compared the accuracy of the new LDL calculation method with the Friedewald method.

Triple Therapy Linked to Mortality Rate in CAD With GI Bleeding

December 06, 2017

Increased mortality at 90 days in patients with lower gastrointestinal bleeding, coronary artery disease

Should Antithrombotics Be Stopped Before Wide-Awake CTR Surgery?

December 05, 2017

Ninety-three of the 99 patients taking AT medication continued their normal regimen through surgery and were included in the analysis.

First PCSK9 Inhibitor Gets FDA Approval for MI, Stroke Prevention

By December 04, 2017

Repatha reduced the risk of heart attack by 27%, the risk of stroke by 21% and the risk of coronary revascularization by 22%.

Patient Admitted Eleven Times for Hypertriglyceridemia-Induced Pancreatitis

By December 01, 2017

The patient was was admitted eleven times over seven years for hypertriglyceridemia-induced pancreatitis.

Is One Statin More Likely to Increase Myopathy Risk Over Another?

By November 14, 2017

Myopathy is frequently cited as a reason for statin therapy cessation.

Statin Use May Up Diabetes Risk in Higher Risk Patients

October 24, 2017

Researchers assessed incident diabetes by annual 75g oral glucose tolerance testing and semiannual fasting glucose among 3,234 participants enrolled in the Diabetes Prevention Program Outcomes Study.

Merck Decides to Put the Brakes on CETP Inhibitor Anacetrapib

By October 13, 2017

The decision follows a review of the clinical profile and discussions with external experts

Better Risk Factor Modification Strategies Needed for Optimal Stroke Prevention

October 12, 2017

Increases in prevalence of hypertension, diabetes, dyslipidemia, smoking, and drug abuse in AIS

PCSK9i Prescription Approval, Abandonment Rate in First Year of Availability

September 28, 2017

The researchers found that 20.8% of patients given a prescription received approval on the first day and that 47.2% ever received approval.

Increased Med Use Over Time Seen in Older Patients of All BMI Classes

By September 22, 2017

Researchers aimed to determine whether the rise in prescription drug use over time varied by age and obesity status.

Effects of Anagliptin vs. Alogliptin on Lipid Profile of T2D Patients

September 19, 2017

The researchers found that there was no significant difference in percent change in LDL-C level between the 2 groups at 24 weeks.

Effects of Statin Use as Primary Prevention Examined in Older Males

September 18, 2017

The researchers found that over the study period statin use was associated with an 18% lower risk of all-cause mortality and non-significantly lower risk of CVD events and stroke.

Evolocumab Safe, Effective in Patients with Diabetes

By September 15, 2017

Compared to placebo, Repatha was not associated with an increased risk of developing new-onset diabetes or worsening glycemia over a median follow-up period of 2.2 years in patients without diabetes at baseline.

Statin Use May Reduce Mortality Risk in COPD

September 08, 2017

Statin exposure associated with lower all-cause, pulmonary mortality

Statins May Lower the Risk of Premature Death in Alcoholic Cirrhosis

By September 08, 2017

Results found that mortality rates were 88 (95% CI; 73-105) per 1,000 years for patients using statins and 127 (95% CI; 114-141) for non-statin patients, the hazard ratio was 0.57 (95% CI; 0.41-0.71).

Updated Storage Information for Praluent

By September 07, 2017

Previously, time out of refrigeration was not to exceed 24 hours at 77ºF.

Link Between Cardiovascular Med Use and Cognitive Impairment Explored

September 01, 2017

No link for impaired cognition, antihypertensive, antithrombotic, lipid-modifying agent use

Does Lowering LDL-C to Ultra-Low Levels Provide Additional Benefit?

By September 01, 2017

The researchers observed these endpoints according to degree of LDL cholesterol reduction after 1 month of treatment.

Familial Chylomicronemia Syndrome Treatment to Get FDA Review

By August 31, 2017

A total of 66 patients with FCS were enrolled in the year-long APPROACH which met its primary endpoint of reduction in triglycerides at 3 months, with a 77% mean reduction in triglycerides for volanesorsen-treated patients.

Anacetrapib Efficacy Examined in Patients with Atherosclerotic Vascular Disease

August 30, 2017

Participants were randomized to 100mg of anacetrapib once daily or matching placebo.

Carbs More Likely to Kill than Fats, Says New Study

August 30, 2017

The investigators found that high-carbohydrate diets are common, with more than half of the people deriving 70 percent of their daily calories from carbs.