Hyperacidity/GERD/ulcers

Study Aims to "Set the Record Straight" on PPIs and Dementia

By July 20, 2017

After multivariable adjustment - which included duration of chronic medical conditions - a modest statistically significant association was only seen for psychomotor speed and attention.

Bismuth-Based Quad Tx Compared to Levofloxacin Triple Tx for <i>H. pylori</i> Infection

July 14, 2017

Addition of bismuth subcitrate to levofloxacin-based triple tx no more effective for H. pylori infection

Proton Pump Inhibitor Use May Up Death Risk

By July 05, 2017

The authors found that compared to the use of H2RA therapy, patients initiated on PPI therapy had a 25% increased risk of death (hazard ratio [HR] 1.25, 95% CI: 1.23-1.28).

Do PPIs Increase the Risk of Dementia?

By June 22, 2017

The data indicated continuous PPI use was tied to a reduced risk of cognitive function decline vs. never use (hazard ratio [HR] 0.78, 95% CI: 0.66-0.93; P=0.005).

Nephron Pharma Responds to Sodium Bicarbonate Shortage

By June 22, 2017

Nephron Pharmaceuticals has joined the effort to abate the nationwide shortage of Sodium Bicarbonate 8.4% by tripling its production of the injectable syringes.

Sodium Bicarbonate Syringe Availability Announced in Response to Shortage

By June 20, 2017

QuVa will be supplying Sodium Bicarbonate PF 8.4% to both current and new customers.

<i>H. Pylori</i> Treatment May Also Improve This Skin Condition

May 08, 2017

Significant decrease in most criteria of rosacea Duluth score in patients cured of H. pylori infection

AGA: Best Practices for Prescribing PPIs

By April 07, 2017

While the benefits of treatment should be weighed against the risks on an individual basis, the AGA has provided recommendations to help clinicians make treatment decisions with regards to PPI use.

PPI Use Significantly Increases Pneumonia Risk in Dementia

March 30, 2017

A retrospective cohort study looked at 786 patients with dementia and new PPI usage and 786 matched patients with dementia without PPI usage.

Acid Suppressants May Up Risk of Recurrent CDI

By March 27, 2017

It may be prudent to assess the need for gastric acid suppressants in patients with CDI, the authors state.

Anti-Reflux Meds May Improve Nasal Symptoms in LPR

March 14, 2017

Decrease in median total nasal resistance score and Nasal Obstruction Symptom Evaluation Score

GERD Treatment May Reduce Healthcare Visits for Acute Respiratory Infections

By February 22, 2017

This population-based study included 21,486 patients diagnosed with GERD and 21,486 matched comparison patients without GERD.

Study Reveals Most Common Drug Interactions Among Older Patients

By January 24, 2017

Findings from a cross-sectional study show that drug interactions are common among community-dwelling older adults and are related to the number of medications and hospitalization in the previous year.

Do PPIs Protect Against Dysplasia, Cancer in Barrett's Esophagus?

By January 11, 2017

In patients with Barrett's esophagus, use of proton pump inhibitors (PPIs) did not lead to dysplasia- or cancer-protective effects.

Is Heartburn Med Use During Pregnancy Tied to Child's Asthma Risk?

By January 09, 2017

Use of acid suppressing agents during pregnancy may increase the risk of asthma in the offspring, according to a study published in The Journal of Allergy and Clinical Immunology.

Quality of Life Assessed in Laryngopharyngeal Reflux

January 09, 2017

For patients with gastroesophageal reflux disease (GERD), the presence of laryngopharyngeal reflux symptoms (LPR) is associated with reduced health-related quality of life (HRQoL), according to a study published online in the Journal of Gastroenterology and Hepatology.

Do Acid Suppression Drugs Up Bacterial Gastroenteritis Risk?

By January 05, 2017

The use of acid suppression medicines was associated with higher rates of Clostridium difficile and Campylobacter positive gastroenteritis in both community and hospital settings, according to a study published in the British Journal of Clinical Pharmacology.

Impact of Anticholinergic Drugs Should Be Considered in Older Patients

January 03, 2017

Anticholinergic medications are frequently prescribed to older adults, but their negative impact should be considered, according to a review published online December 23 in the Journal of Pharmacy Practice and Research.

Significant Number of Preemies Receive Gastroesophageal Reflux Meds

November 30, 2016

Seventy-seven percent of those on medications started after NICU discharge; prolonged use common

PPI Use Tied to Increased Risk of Gastric Polyps

November 28, 2016

Long-term proton pump inhibitor (PPI) use is associated with increased risk of fundic gland polyps (FGPs).

Acid Suppression Drugs Tied to Increased Kidney Stone Risk, CKD

November 21, 2016

Both proton pump inhibitors and histamine receptor-2 (H2) blockers were examined.

Proton Pump Inhibitor Safety Called into Question as New Risk Emerges

November 16, 2016

The extent of risk also depended on the specific PPI taken.

Long-term PPI Use Reduces Bleeding-Related Mortality in Cirrhosis Patients

By November 14, 2016

Long-term use of proton pump inhibitors (PPIs) reduces bleeding-related mortality in patients with cirrhosis and variceal bleeding, a prospective study reported at The Liver Meeting® 2016.

Does Concomitant PPI Use Affect Efficacy of Elbasvir/Grazoprevir?

By November 12, 2016

Consistent concomitant use of proton pump inhibitors (PPIs) with elbasvir/grazoprevir (EBR/GZR) had no clinically significant effect on 12-week sustained viral response (SVR12) rates in patients with hepatitis C virus (HCV) genotype (GT)1 or GT4 infection with and without cirrhosis, according to research presented at The Liver Meeting® 2016

Long-Term PPI Use Discouraged for HIV-1-Infected Patients

By October 30, 2016

Long-term use of proton pump inhibitors (PPIs) might increase microbial translocation and innate immune activation but not enterocyte turnover or T-cell activation among people infected with HIV-1, according to research findings reported at IDWeek 2016.

Classwide Update for PPIs Warns of Cutaneous, Systemic Lupus Erythematosus

By October 28, 2016

PPIs are indicated for the treatment of erosive esophagitis and gastroesophageal reflux disease (GERD).

Best Criterion for ID'ing Gastroesophageal Reflux

October 28, 2016

Epithelial thickness seems to be a marker for gastroesophageal reflux disease (GERD), according to research published in Clinical Gastroenterology and Hepatology.

PPIs and Gastroenteritis Hospitalization: What's the Risk?

By October 28, 2016

Use of proton pump inhibitors (PPIs) was tied to a higher risk of infectious gastroenteritis hospitalization with increasing risk among increasing doses.

PPIs and Microscopic Colitis: What's the Link?

By October 14, 2016

Proton pump inhibitor (PPI) use may potentially be associated with microscopic colitis according to a new review of currently available evidence, published in the journal, Annals of Pharmacotherapy.

Rx-to-OTC Switch for PPIs Linked to Reduced PCP Visits for GERD

By October 07, 2016

The over-the-counter (OTC) availability of proton pump inhibitors (PPIs) was associated with a significant decrease in the rate of primary care physician (PCP) visits for gastroesophageal reflux disease (GERD) in the U.S.