<3yrs: not recommended. Onset approx ≤15 minutes, peak approx 1 hr, duration approx 3.5–4.5 hrs. ≥3yrs: Give SC, either by injection or continuous infusion external pump. SC inj: give 15 minutes before meal or immediately after a meal; use with an intermediate or long-acting insulin. Rotate inj sites. Continuous SC infusion pump: do not use diluted or mixed insulins in external pumps; change the Humalog in the reservoir at least every 7 days, change the infusion sets and insertion site at least every 3 days.
During episodes of hypoglycemia.
Instruct patients on diet, exercise, blood or urine testing, proper administration of insulin, change in species of origin, type or purity of insulin, and management of hypoglycemia. Dosage increase may be required during infection, illness, stress, trauma, and pregnancy. Dosage decrease may be needed with renal or hepatic dysfunction. Pregnancy (Cat.B). Nursing mothers.
Potentiated by oral antidiabetic agents, pramlintide, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by corticosteroids, isoniazid, niacin, danazol, diuretics, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, atypical antipsychotics. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. When mixing insulin lispro with other insulins, draw insulin lispro into syringe first and inject mixture immediately.
Hypoglycemia, hypokalemia, local or systemic allergy, lipodystrophy, edema.
Humalog Mix75/25, Humalog vials (10mL)—1; Humalog Mix, Humalog KwikPen (disposable insulin delivery device) (3mL)—5; Humalog cartridges (3mL)—5; HumaPen MEMOIR (inj device, uses Humalog cartridges)—1; HumaPen LUXURA HD (inj device, uses Humalog cartridges)—1