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HORIZANT
Nonnarcotic analgesics
Restless legs syndrome
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Drug Name:

HORIZANT Rx

Generic Name and Formulations:
Gabapentin enacarbil 300mg, 600mg; extended-release tablets.

Company:
XenoPort, Inc

Therapeutic Use:

Indications for HORIZANT:

Postherpetic neuralgia.

Adult:

Swallow whole. Take with food. Initially 600mg in the AM for 3 days, then increase to 600mg twice daily beginning on Day 4 (no additional benefit seen with >1200mg daily dose). If dose is not taken at recommended time, skip this dose, and the next dose should be taken at the time of the next scheduled dose. Renal impairment: CrCl 30–59mL/min: initially 300mg in the AM for 3 days, then 300mg twice daily; may increase to 600mg twice daily if needed or tolerated. CrCl 15–29mL/min: 300mg in the AM on Day 1 and Day 3, then continue with 300mg in AM; may increase to 300mg twice daily if needed. CrCl <15mL/min: Maintenance: 300mg every other day in the AM, may increase to 300mg once daily if needed. CrCl <15mL/min on hemodialysis: Maintenance: 300mg after every session, may increase to 600mg if needed. Tapering doses: see literature.

Children:

Not studied.

Warnings/Precautions:

Not interchangeable with other gabapentin products. Not recommended for patients who are required to sleep during the day and remain awake at night. May cause significant driving impairment; do not drive until impairment is assessed. Epilepsy. Monitor for worsening of depression, suicidal thoughts/behavior, and unusual changes in mood/behavior. Multiorgan hypersensitivity; evaluate if signs/symptoms develop. Renal impairment. Avoid abrupt cessation (see full labeling). Elderly. Pregnancy (Cat. C). Nursing mothers: not recommended.

Interactions:

Avoid alcohol. Increased somnolence/sedation with morphine.

Adverse Reactions:

Somnolence/sedation, dizziness, headache, nausea, dry mouth, fatigue, irritability, feeling drunk, vertigo.

Metabolism:

Hepatic.

Elimination:

Renal (major), fecal.

How Supplied:

Tabs—30

HORIZANT

  • 600mg tablets (Qty:30)
  • appx. price $224.00
GoodRx

Indications for HORIZANT:

Treatment of moderate-to-severe primary restless legs syndrome.

Adult:

Swallow whole. Take with food. 600mg once daily at about 5pm (no additional benefit seen with 1200mg dose). If dose is not taken at recommended time, next dose should be taken the following day. Renal impairment: CrCl 30–59mL/min: initially 300mg/day and increase to 600mg as needed. CrCl 15–29mL/min: 300mg/day. CrCl <15mL/min: 300mg every other day. CrCl <15mL/min on hemodialysis: not recommended.

Children:

Not studied.

Warnings/Precautions:

Not interchangeable with other gabapentin products. Not recommended for patients who are required to sleep during the day and remain awake at night. May cause significant driving impairment; do not drive until impairment is assessed. Epilepsy. Monitor for worsening of depression, suicidal thoughts/behavior, and unusual changes in mood/behavior. Multiorgan hypersensitivity; evaluate if signs/symptoms develop. Renal impairment. Avoid abrupt cessation (see full labeling). Elderly. Pregnancy (Cat. C). Nursing mothers: not recommended.

Interactions:

Avoid alcohol. Increased somnolence/sedation with morphine.

Adverse Reactions:

Somnolence/sedation, dizziness, headache, nausea, dry mouth, fatigue, irritability, feeling drunk, vertigo.

Metabolism:

Hepatic.

Elimination:

Renal (major), fecal.

How Supplied:

Tabs—30

HORIZANT

  • 600mg tablets (Qty:30)
  • appx. price $224.00
GoodRx

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