Hepatitis B Adult Renal Dosing
| HEPATITIS B ADULT RENAL DOSING | ||||
|---|---|---|---|---|
| Brand | Generic | Creatinine Clearance (CrCl) | ||
| CrCl 30–49mL/min | CrCl 10–29mL/min | CrCl <10mL/min | ||
| Baracludea,b | entecavir | Nucleoside-naïve patients | ||
| 0.25mg once daily or 0.5mg every 48hrs | 0.15mg once daily or 0.5mg every 72hrs | 0.05mg once daily or 0.5mg every 7 days | ||
| Lamivudine-refractory or decompensated liver disease | ||||
| 0.5mg once daily or 1mg every 48hrs | 0.3mg once daily or 1mg every 72hrs | 0.1mg once daily or 1mg every 7 days | ||
| Epivir-HBV | lamivudine | 100mg for 1st dose then 50mg once daily | CrCl 15–29mL/min:
100mg for 1st dose then 25mg once daily |
CrCl 5–14mL/min:
35mg for 1st dose then 15mg once daily |
| CrCl <5mL/min:
35mg for 1st dose then 10mg once daily. |
||||
| Hepsera | adefovir | 10mg every 48hrs | 10mg every 72hrs | On hemodialysis:
10mg every 7 days after dialysis |
| Not on hemodialysis:
Not recommended |
||||
| Intron A | interferon alfa-2b | — | — | — |
| Pegasys | peginterferon alfa-2a | — | — | ESRD on hemodialysis:
135mcg SC once weekly |
| Tyzeka | telbivudine | 600mg once every 48hrs or 20mL once daily | CrCl <30mL/min:
(not on dialysis): 600mg once every 72hrs or 10mL once daily |
ESRD:
600mg every 96hrs (give after dialysis session) or 6mL once daily |
| Viread | tenofovir | 300mg every 48hrs | 300mg every 72–96hrs | Not recommended |
| On hemodialysis:
300mg once per week or after a total of 12hrs of dialysis |
||||
| NOTES | ||||
|
a For doses less than 0.5mg, Baraclude Oral Solution is recommended. b If administered on hemodialysis day, give after hemodialysis. ESRD = end-stage renal disease; SC = subcutaneous (Rev. 4/2013) |
||||
