Gynecologic Cancers

Age to Stop Cervical Cancer Screening Depends on Test Used

November 05, 2018

The model predicted lifetime risk for cervical cancer to be 1 in 45 for women without HPV vaccination who have never been screened. Incremental decreases in cancer risk were seen later in life with increasing age at which women stopped cytology screening from 55 to 75 years.

Low-Dose Aspirin May Reduce Ovarian Cancer Risk

October 12, 2018

When current use vs. non-use of any aspirin was evaluated, significant associations between aspirin and cancer risk were not observed, regardless of aspirin dose.

Gardasil 9 Approved for Use in Women and Men 27 Through 45 Years Old

By October 09, 2018

The approval of the expanded age range was based on data from a clinical trial which evaluated the efficacy of Gardasil (quadrivalent human papillomavirus recombinant vaccine) in 3253 women 27-45 years of age with a median duration of follow-up of 3.5 years post-dose 3.

Newer Hormonal Contraception May Cut Ovarian Cancer Risk

September 27, 2018

The researchers identified 1249 incident ovarian cancers during 21.4 million person-years; 478 ovarian cancers were recorded among 13,344,531 person-years for ever users of hormonal contraception, while never users had 771 ovarian cancers during 8,150,250 person-years.

Capsule Formulation of Ovarian Cancer Treatment Discontinued

By September 04, 2018

The Company has not disclosed a reason for the medication discontinuation, however in 2017, the FDA reported that olaparib capsules were being phased out of the US market.

USPSTF Updates Guidance for Cervical Cancer Screening

August 22, 2018

The researchers found that screening can detect high-grade precancerous cervical lesions and cervical cancer, resulting in substantial reductions in cervical cancer incidence and mortality.

Link for Asbestos-Free Talcum Powder, Cancer Not Clear

July 19, 2018

Perineal use of talc-based body powder is classified as "possibly carcinogenic to humans."

Ready-to-Administer Gemcitabine Formulation Gets FDA Approval

By July 18, 2018

Infugem utilizes a novel technology that enables cytotoxic oncology products to be premixed in a sterile setting and to be supplied to prescribers in RTA infusion bags.

Higher Risk of In-Situ Breast CA, Ovarian Tumors With Fertility Tx

July 17, 2018

Researchers examined the risks of ovarian, breast, and corpus uteri cancer in 255,786 women who underwent assisted reproduction, with 2,257,789 person-years of follow-up.

Mammography Use Tied to Other Preventive Tests in Older Women

July 09, 2018

The researchers found that women who underwent index screening mammography were more likely than unscreened women to later undergo Papanicolaou test (odds ratio, 1.49), bone mass measurement (odds ratio, 1.70), and influenza vaccine (odds ratio, 1.45).

Mirvetuximab Gets Fast Track Status for Platinum-Resistant Ovarian Cancer

By June 18, 2018

Mirvetuximuab soravtansine uses a humanized FRα-binding antibody to target antibody-drug conjugates specifically to FRα-expressing cancer cells and a potent anti-tumor agent, DM4, to kill the targeted cancer cells.

Keytruda Gains First Gynecologic Cancer Indication

By June 13, 2018

Data showed ORR was 14.3% (95% CI, 7.4-24.1) with 2.6% achieving complete response and 11.7% achieving partial response. Of the 11 responders, median DOR was not yet reached at the time of analysis; 91% of patients, however, had a DOR of ≥6 months.

Avastin Plus ChemoTx Approved for Advanced Ovarian Cancer After Resection

By June 13, 2018

Study patients who received Avastin plus chemotherapy followed by Avastin alone, had a greater median PFS vs patients who received chemotherapy alone (18.2 months vs 12 months; hazard ratio [HR] 0.62, 95% CI, 0.52-0.75; P<.0001).

HPV Vaccination May Offer Protection Against Cervical Precancer

By May 11, 2018

The authors concluded, "There is high-certainty evidence that HPV vaccines protect against cervical precancer in adolescent girls and young women aged 15 to 26," while also indicated that future studies should have long-term follow-up.

Long-Term Cardiovascular Risk for Endometrial Cancer Survivors

May 08, 2018

The researchers found that there were increased cardiovascular risks among endometrial cancer survivors for phlebitis, thrombophlebitis, and thromboembolism (hazard ratio, 2.07); pulmonary heart disease (hazard ratio, 1.74); and atrial fibrillation (hazard ratio, 1.5).

Mortality Risk Persists for Cancer Tied to Prenatal DES Exposure

May 04, 2018

Women with DES-related clear-cell adenocarcinoma had 27-fold higher mortality at 10 to 34 years

New Drug Combo Ups Survival in HER2/neu Uterine Serous Cancer

April 18, 2018

Among 41 patients with stage III or IV disease undergoing primary treatment, the median progression-free survival was 9.3 versus 17.9 months in the control versus experimental groups (hazard ratio, 0.40).

Personalized Cancer Vaccine Looks Promising in Early Study

By April 12, 2018

The researchers enrolled 25 platinum-pretreated, immunotherapy-naïve patients with recurrent advanced epithelial ovarian cancer (EOC) for the trial.

Rubraca Approved as Maintenance Treatment for Recurrent Ovarian Cancer

By April 06, 2018

The new approval was based on data from the Phase 3 ARIEL3 clinical trial (N=564).

Vigil Immunotherapy Tolerated Well for Recurrent Ovarian CA Tx

March 27, 2018

In the trial a personalized engineered autologous tumor cell vaccine was created incorporating rhGM-CSF DNA for enhanced antigen presentation and bifunctional shRNAfurin, which inhibits endogenous immunosuppression.

Genetic Assay of PAP Tests May Help Dx Endometrial, Ovarian CA

March 26, 2018

The researchers found that 81% of Pap brush samples from 382 endometrial cancer patients were positive, including 78% with early-stage disease. Among 245 ovarian cancer patients, sensitivity was 33%, including 34% with early-stage disease.

Metformin, Statin Use and Ovarian Cancer Risk: What's the Link?

February 27, 2018

The researchers found that 303 women were diagnosed with ovarian cancer during the follow-up period. Metformin was not associated with the incidence of ovarian cancer (hazard ratio, 1.02) compared to other oral antidiabetic medications.

USPSTF Issues Recommendation Statement on Ovarian Cancer Screening

February 13, 2018

Adequate evidence was also found suggesting that the harms of screening may be substantial in some cases, including unnecessary surgery in women without cancer. Based on these findings, the USPSTF concludes with moderate certainty that the harms of ovarian cancer screening outweigh the potential benefits.

Hyperthermic intraperitoneal chemotherapy with surgery increases survival for epithelial ovarian cancer patients

January 22, 2018

Patients with stage 3 epithelial ovarian cancer treated with hyperthermic intraperitoneal chemotherapy (HIPEC) in addition to cytoreductive surgery and neoadjuvant chemotherapy experienced increased overall and recurrence-free survival.

Normal tissue BRCA1 methylation associated with risk for high-grade ovarian cancer

January 19, 2018

BRCA1 promoter methylation in normal white blood cells (WBCs) was linked to risk for high-grade serous ovarian cancer (HGSOC).

Add-On Hyperthermic Intraperitoneal Chemotherapy Assessed in Ovarian CA

January 18, 2018

The researchers found that 89 and 81% of patients who underwent cytoreductive surgery without HIPEC and with HIPEC, respectively, had events of disease recurrence or death in the intention-to-treat analysis (hazard ratio, 0.66).

<i>BRCA1</i> Promoter Methylation and Ovarian CA Risk: Is There a Link?

January 16, 2018

Only patients with HGSOC had elevated methylation (9.6%; odds ratio, 2.91), in contrast to 5.1 and 4.0% of patients with non-serous ovarian cancer and low-grade serous ovarian cancer (LGSOC), respectively.

Levonorgestrel-Releasing IUD May Benefit in Early-Grade Endometrial Cancer

December 20, 2017

The researchers found that 15 of the 32 evaluable patients at the 6-month time point had complex atypical hyperplasia (47%), 9 had G1 endometrial cancer (28%), and 8 had grade 2 endometrial cancer (25%).

Can Co-Testing Support Longer Cervical Cancer Screening Intervals?

November 28, 2017

Regardless of the cytology result, 5-year ≥CIN3 risks for an HPV-negative co-test nearly matched the performance of a negative co-test for each successive round of screening (0.114, 0.061, and 0041%, respectively).

Opioid Rx Patterns Assessed Post-Hysterectomy

November 10, 2017

Patients reported using about half of the opioids prescribed, with a median excess of 110 oral morphine equivalents.