Select therapeutic use:
Indications for GRANISOL:
Prevention of nausea and vomiting associated with chemotherapy (including high-dose cisplatin) or with radiation (including total body irradiation and fractionated abdominal radiation).
Chemotherapy: give only on the days chemo is given. 2mg once daily up to 1 hour before chemo; or, 1mg up to 1 hour before chemo, then 1mg 12 hours after 1st dose. Radiation: 2mg once daily within 1 hour of radiation.
Pre-existing arrhythmias or cardiac conduction disorders. Increased risk of QT prolongation: cardiac disease, on cardio-toxic chemotherapy, electrolyte abnormalities and/or concomitant drugs that prolong the QT interval. Abdominal surgery. May mask progressive ileus and/or gastric distention. Pregnancy (Cat.B). Nursing mothers.
Caution with drugs that affect CYP450 or drugs known to prolong the QT interval and/or are arrhythmogenic.
Selective 5-HT3 receptor antagonist.
Headache, asthenia, diarrhea, constipation, abdominal pain; QT prolongation.