Gout Treatments

• 50mg 3 times daily until pain relief; rapidly taper and discontinue

• Use lowest effective dose and shortest duration

• Discontinue if experiencing severe side effects

• 750mg followed by 250mg every 8 hours until pain relief

• EC-Naprosyn not recommended

• Use lowest effective dose and duration

• 825mg followed by 275mg every 8 hours until pain relief

• 825mg followed by 275mg every 8 hours until pain relief

• 1–1.5g once daily for 1 day then 1g once daily until attack subsides

• 200mg twice daily until pain relief; usual duration 7 days

• Use lowest effective dose and shortest duration

• Take with food

• Max dose: 400mg per day

• Gout treatment: 1.2mg at first sign of gout flare, then 0.6mg 1 hour later; max 1.8mg over a 1 hour period; may be given during prophylaxis at max 1.2mg at first sign of flare, then 0.6mg 1 hour later, wait 12 hours, then resume prophylactic dose. Concomitant CYP3A4 and/or P-glycoprotein inhibitors, severe renal or hepatic impairment: reduce dose (see literature).

• IA: Small joint: 4–10mg; medium joint: 10–40mg; large joint: 20–80mg

• Gently move joint after IA inj to aid mixing of susp with synovial fluid

• IA: Individualize. Average intra-articular dose: 2–20mg. Large joints: 10–20mg. Small joints: 2–6mg. Usual frequency of injection into a single joint is every 3–4 weeks.

• Initial: 100mg daily. Increase by increments of 100mg daily at weekly intervals until serum uric acid level ≤6mg/dL (minimizes flare-ups)

• Mild: 200–300mg per day

• Severe: 400–600mg per day

• Take with food

• Ensure adequate fluid intake to yield ≥2 liters daily urine output

• Maintain alkaline or neutral urine

• Administer in divided doses

• Max dose: 800mg per day and 300mg per dose

• Discontinue if rash appears

• Gout prophylaxis: >16yrs: 0.6mg once or twice daily; max 1.2mg/day. Concomitant CYP3A4 and/or P-glycoprotein inhibitors, severe renal or hepatic impairment: reduce dose (see literature).

• ≥18yrs: initially 40mg once daily; if serum uric acid is not <6mg/dL after 2 weeks, may increase to 80mg once daily.

• Gout flare prophylaxis, with an NSAID or colchicine, upon initiation of therapy and for up to 6 months, is recommended.

• 8mg once every 2 weeks

• Discontinue oral urate-lowering agents before starting; do not institute while on pegloticase therapy

• Give by IV infusion over at least 2 hours and premedicate with antihistamines and corticosteroids

• Slow rate, or stop and restart at lower rate, if infusion reaction occurs; observe at least 1 hour post-infusion

• Initial: 250mg twice daily for 1 week

• Maintenance: 500mg twice daily

• Take with plenty of fluids

• Maintain alkaline or neutral urine

• Reduce dose if GI intolerance occurs

• Initial: 1 tablet daily for 1 week

• Maintenance: 1 tablet twice daily

• Take with plenty of fluids

• Maintain alkaline or neutral urine

• Reduce dose if GI intolerance occurs