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Generic Name and Formulations:

Glipizide 2.5mg, 5mg, 10mg; ext-rel tabs.


Pfizer Inc.

Select therapeutic use:

Indications for GLUCOTROL XL:

Adjunct to diet and exercise in type 2 diabetes mellitus.


Swallow whole. Initially 5mg with breakfast. Usual range: 5–10mg once daily; max 20mg daily. Concomitant other hypoglycemics or transferring to Glucotrol XL: see full labeling.


Not established.


Type 1 diabetes, diabetic ketoacidosis, with or without coma.


Increased risk of cardiovascular mortality. Renal or hepatic impairment. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with extended therapy. Risk of hemolytic anemia in G6PD deficiency; consider non-sulfonylurea alternative. Monitor urine and blood glucose. Impaired GI function or GI narrowing (XL). Discontinue if jaundice occurs or skin reactions persist. Malnourished. Elderly. Debilitated. Pregnancy (Cat.C): consider using insulin instead. Nursing mothers: not recommended.


May be potentiated by NSAIDs, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, quinolones, β-blockers, oral miconazole (possibly), fluconazole. May be antagonized by thiazides, diuretics, steroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, niacin, sympathomimetics, calcium channel blockers, isoniazid. Monitor closely for hypoglycemia when concomitant drugs that affect glucose metabolism and upon withdrawal. May be antagonized by colesevelam; administer glipizide ≥4hrs prior to colesevelam. Disulfiram-like reaction with alcohol (rare). Monitor for 1–2 weeks if transferring from long-acting sulfonylureas.

See Also:


Pharmacological Class:

Sulfonylurea (2nd generation).

Adverse Reactions:

Hypoglycemia, tremor, asthenia, diarrhea, flatulence, allergic skin reactions, photosensitivity, blood dyscrasias, hyponatremia, dizziness, drowsiness, headache; rare: cholestatic jaundice, hepatic porphyria.

Generic Availability:


How Supplied:

XL tabs 2.5mg—30; XL tabs 5mg, 10mg—100, 500; Tabs—100

GLUCOTROL XL 5mg tablets (Qty:90)

appx. price $146.00