Perrigo Begins Shipment of Generic Protopic

Perrigo Begins Shipment of Generic Protopic
Perrigo Begins Shipment of Generic Protopic

Perrigo announced the availability of Tacrolimus Ointment, the generic version of Astellas' Protopic Ointment.

Protopic is an immunomodulator that is indicated as second-line therapy for short-term and non-continuous chronic treatment of moderate to severe atopic dermatitis in non-immunocompromised patients when other topical therapies are inadvisable or ineffective. It has been shown that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This effect has been shown to prevent the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines (such as interleukin-2, gamma interferon).

RELATED: Topical Treatment of Atopic Dermatitis: A Review

Protopic Ointment is available in 0.03% and 0.1% strengths. Shipment of these products has begun.

For more information call (866) 634-9120 or visit Perrigo.com.

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