To examine the occurrence of adverse reactions in this patient population, researchers from John Hopkins University, Baltimore, Maryland, conducted a retrospective analysis of IBD patients who received IV iron infusions between 2010 and 2014 in the commercial claims database, MarketScan.

Akynzeo IV combines fosnetupitant (prodrug of netupitant), a substance P/NK1 receptor antagonist, and palonosetron, a 5-HT3 receptor antagonist.

The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Heavy use in Crohn's, heavy or moderate use in ulcerative colitis tied to increased risk of death

Factors associated with C. difficile infection incidence in the 30-day postoperative period after controlling for other variables include stoma reversal (odds ratio, 2.701; P<.001), smoking (odds ratio, 1.520; P<.022), steroids (odds ratio, 1.677; P<.048), and disseminated cancer.

Results showed that 46% (n=6) of substudy patients improved their histological fibrosis stage, while 38% maintained (n=5), and 15% experienced 1 stage progression (n=2).

In the U.S., ferric citrate is commonly found in dietary supplements and ferric EDTA is often used as a food additive.

Omeprazole ODT utilizes MelTech technology that allows the tablet to dissolve in the mouth without water.

The researchers found that the risk of acute pancreatitis was not increased comparing 49,374 DPP-4I initiators with 132,223 sulfonylurea initiators and comparing 57,301 DPP-4I initiators with 32,612 thiazolidinedione initiators.

While glucagon is often used for the treatment of esophageal food impaction, its effectivess, based on several studies, has been inconsistent.

Each additional 10cm greater waist circumference at early childhood was associated with 1.99 higher odds of elevated ALT at mid-childhood, in multivariable-adjusted models.

"As graphic as it is, we have to show parents because teens are going online looking for challenges and recreating them," said education specialist Stephen Enriquez.

The researchers found that 7.6% of included children were prescribed a histamine-2 receptor antagonist (H2RA), 1.7 percent a proton pump inhibitor (PPI), and 16.6% an antibiotic during the first 6 months of life.

Firvanq will replace CutisPharma's FIRST-Vancomycin Unit-of-Use Compounding Kit.

Bonjesta is a multilayer, extended-release formulation that is designed to provide both fast-acting and long-lasting symptom relief.

Livantra may help rate of survival without transplantation or help improve survival until patients can receive a new liver.

The wearable system was found to work as well as more invasive methods.

Data added to the labeling includes first-of-their-kind pharmacokinetic studies demonstrating negligible to low transfer of CIMZIA through placenta and minimal transfer to breast milk from mother to infant.

This first population-based study, found that DPP-4 inhibitors were associated with an increased risk of inflammatory bowel disease.

The researchers found that after adjusting for body mass index, physical activity, smoking, alcohol, energy, saturated fat and cholesterol intake, the odds of NAFLD and IR were increased in association with high consumption of total meat.

Among humans who died of sepsis, bacterial taxa detected in their brains were distinct from those who died of noninfectious causes and were correlated with S100A8/A9 expression.

The result comparisons found an overall agreement in the pre-therapy cohort between the breath test and the reference biopsy result of 98.3% (95 CI: 95.2%-99.7%).

the Phase 3 'SOLUTION' study of Sollpura did not meet the primary endpoint of non-inferiority to an active-comparator in the coefficient of fat absorption (CFA).

The GIDAC recommendations are provided to the FDA but they are not binding. The FDA has set a target PDUFA action date of June 2018.

If approved, prucalopride will be the only readily available 5-HT4 agonist for adult CIC in the U.S.