Gastrohepatic Disorders

IDSA: New Clinical Practice Guidelines on Infectious Diarrhea Management

By October 19, 2017

The expert panel states that for the majority of patients with diarrhea, diagnostic testing is unnecessary.

Treating Iron Deficiency Anemia in Patients With Inflammatory Bowl Disorder

By October 19, 2017

Despite its frequency, iron deficiency anemia in patients with IBD it is often overlooked in clinical settings.

Proton Pump Inhibitor Use Linked to Two Distinct Dermatological Reactions

By October 18, 2017

The case involved a 32-year-old male who was prescribed pantoprazole after initially presenting with dyspepsia-like symptoms.

PPI Use and First-Time Stroke, MI: What's the Link?

October 18, 2017

After adjustment for age, sex, comorbidities, and concomitant medications, the rates of ischemic stroke and MI were significantly increased with current PPI exposure (hazard ratios, 1.13 and 1.31).

Mesalamine Formulation Switch Linked to Acute Renal Failure in UC Patient

By October 17, 2017

The 35-year-old male from Hawaii maintained clinical remission with Lialda, a once-daily formulation of mesalamine, and infliximab.

Intrahepatic Cholestasis Following Regular Consumption of Herbal Tea

By October 17, 2017

The case involved a 30-year-old female with a history of anxiety and migraine who presented with complaints of malaise, right upper quadrant pain, worsening jaundice, dark colored urine, and itching; these symptoms had been going on for a few weeks.

Irritable Bowel Syndrome Treatments

October 16, 2017

Drug therapy for the treatment of irritable bowel syndrome (IBS).

Same-Day vs. Split Dose Bowel Prep for Colonoscopy Compared

By October 16, 2017

Results showed that adenoma detection rate (ADR) did not differ between groups. Additionally willingness to repeat and tolerability did not differ.

New Therapeutic Drug Monitoring Test for Ustekinumab Announced

By October 16, 2017

By measuring drug and antibody concentrations physicians can adapt treatment strategies and guide patients toward more personalized medicine.

Noninvasive Test Monitors Healing Status in Crohn's Disease Patients

By October 16, 2017

The PROMETHEUS Monitr Crohn's Disease test can be used as an adjunct to endoscopy or by itself between endoscopies.

Fecal Transplant Efficacy Examined for Chronic Liver Disease

October 16, 2017

The researchers found that by week 26, three of six patients had a ≥50% decrease in alkaline phosphatase (ALP), with an average decrease of 250 versus 10 for responders versus nonresponders.

Defecation Posture Modification Device Found to Be Beneficial

October 16, 2017

Significant reductions in bowel movement duration, straining patterns and increase in bowel emptiness

ACG: Prevalence of Burnout Examined Among Gastroenterologists

October 16, 2017

Factors associated with burnout include female sex, spending more hours on domestic chores, child care

Ulcerative Colitis Treatments

October 13, 2017

Medications for the treatment, induction of remission, and maintenance of ulcerative colitis.

Symproic Now Available for Opioid-Induced Constipation

By October 12, 2017

Symproic, initially approved as a CII controlled substance in March 2017, was officially descheduled by the Drug Enforcement Agency (DEA) in September 2017.

Early-Life Antibiotic Use and Celiac Disease: Is There an Association?

October 10, 2017

The researchers found that exposure to and frequency of use of any antibiotic assessed in the study in early life or before seroconversion was not associated with the risk of developing islet or celiac disease autoimmunity.

Impact of Early Azathioprine Use on Crohn's Disease Progression Evaluated

October 02, 2017

Prior bowel resection, smoking, and low hemoglobin tied to Crohn's-related surgery

PPI Effectiveness Compared for Erosive Esophagitis Management

By September 28, 2017

The researchers chose endoscopic healing rates (at 4 and 8 weeks) as the primary efficacy outcome.

Post-Op Outcomes for Individualized vs. Standard Blood Pressure Tx

September 27, 2017

The researchers found that the primary outcome event occurred in 38.1 and 51.7% of patients assigned to the individualized treatment group and standard treatment strategy group, respectively.

Salt Intake Beliefs Examined in Patients Undergoing Hemodialysis

September 25, 2017

Patients who had versus those who had not received a transplant had a significantly higher score for the subscale of perceived seriousness for no reduction of sodium intake (P<0.01).

NDA Submitted for Thrombocytopenia Treatment

By September 22, 2017

The results from Phase 3 trials demonstrated efficacy and safety in patients with severe thrombocytopenia and with CLD.

Hair Regrowth in Alopecia Patients After Fecal Transplant for Recurrent CDI

By September 22, 2017

These 2 cases suggests that fecal transplants can have a profound immunological response not only limited to intestinal effects, say the authros.

Best Practice Recs for <i>H. pylori</i> Treatment Reviewed

By September 22, 2017

The authors stated that the recommended approach should be based on local and individual antibiotic resistance patterns.

FDA: Cases of Severe Liver Injury with PBC Drug Due to Incorrect Dosing

By September 21, 2017

Patients with moderate to severe decline in hepatic function have been receiving excessive dosing at a frequency higher than what is recommended for this specific population.

Concomitant Naloxegol Tx Evaluated for Opioid Dose Impact

September 21, 2017

The researchers found that the mean daily numerical rating scale average pain scores varied from 4.5 to 4.8 for all groups in the 652 participants in KODIAC-04, and were 4.6 for each group of the 700 participants in KODIAC-05.

First Duodenoscope with Disposable Distal Cap Cleared by FDA

By September 20, 2017

The Pentax ED34-i10T duodenoscope is intended to provide visualization and access to the upper gastrointestinal tract to treat bile duct disorders and other upper GI problems.

PPIs Should Be Focus for Deprescribing, Says New Research

September 20, 2017

From 2000 to 2016 there was little change in the extent of appropriate PPI use reported in 34 international studies. Patient-centered deprescribing, academic detailing, educational programs, and safety notifications were interventions for addressing inappropriate use.

Antibiotic Class Linked to Increased Risk of GI Perforation

By September 18, 2017

The researchers compared a cohort of 17,510 individuals diagnosed with GI perforation to a matched group of 1,751,000 controls.

What Are the Clinical Characteristics of Hepatic Sarcoidosis?

By September 18, 2017

Most patients were asymptomatic and the diagnosis was discovered in pursuit of other abnormal biochemical tests and imaging studies. In the majority of patients, alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) were elevated (88 and 90%, respectively).

Treating HCV Infection May Prevent Development of Chronic Kidney Disease

By September 18, 2017

Using several databases, the researchers examined the association of HCV infection with the incidence of CKD.