Gastrohepatic Disorders

Celiac Disease Linked to Increased Risk of Pneumococcal Infection

By August 15, 2017

After adjusting for socioeconomic index, diabetes, level of education, sex and age, an increased risk of pneumococcal infection among celiac disease patients was noted.

Light, Moderate Alcohol Intake May Protect Against All-Cause, CVD Death

August 15, 2017

Risk of mortality for all causes, cancer up for adults with heavy alcohol consumption, binge drinking.

AGA: Recommendations for Monitoring Drug Therapy in IBD

By August 14, 2017

To optimize drug concentration and improve outcomes, therapeutic drug monitoring is used to check the trough concentration and evaluate for the presence of anti-drug antibodies.

Diuretic Linked to Acute Pancreatitis in Patient with Coronary Artery Disease

By August 14, 2017

Furosemide-induced acute pancreatitis can occur several hours to up to 7 weeks after starting treatment; dose may also play a role. This patient, the authors note, fell into the category of "long-term latency" and "low-dosage (40mg)"

Gastroenteritis Hospitalizations Down with Rotavirus Vaccine Introduction

August 11, 2017

The researchers found that 16% of the 1,253,951 AGE-related hospitalizations among children aged <5 years were coded as a rotavirus-related hospitalization.

Cases of Cyclosporiasis on the Rise, CDC Warns

By August 08, 2017

A total of 206 cases of Cyclospora infections have been reported to the CDC as of August 2, 2017 among individuals who became ill on or after May 1, 2017.

Mytesi Granted Orphan Drug Designation for Short Bowel Syndrome

By August 07, 2017

Clinical studies of Mytesi have shown that the most common adverse reactions were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough, and flatulence (3.1%).

Labeling Updated for Multiple Drugs Indicated for Opioid-Induced Constipation

By August 07, 2017

The prescribing information has been updated to provide clarification of the opioid-induced constipation (OIC) indication.

Stool Softeners Recalled Due to Possible Contamination

By August 03, 2017

Rugby Laboratories announced a voluntary recall of all lots of Diocto Liquid and Diocto Syrup (docusate sodium solutions) due to a risk of contamination with Burkholderia cepacia.

Ipragliflozin vs. Pioglitazone in T2DM Complicated by Liver Disease

August 03, 2017

"Compared with pioglitazone, ipragliflozin exerts equally beneficial effects on NAFLD and glycemic control during the treatment of patients with type 2 diabetes complicated by NAFLD," the authors write.

Obeticholic Acid + Statin Shows Rapid Reversal of LDL Rise in NASH Patients

By August 02, 2017

The mean LDL change from baseline to Week 16 were as follows: placebo: -48 mg/dL, OCA 5mg: -40mg/dL, OCA 10mg: -40mg/dL, and OCA 25mg: -45mg/dL.

Serum &#947;-Glutamyltransferase Levels May ID MetS in Children

July 28, 2017

After adjustment for age, household income, and residential area, the multivariable-adjusted odds ratios for MetS for the upper stratum were 5.79 and 6.20 in boys and girls, respectively.

Clinically Meaningful Reductions in HIV-Related Diarrhea with Long-Term Crofelemer

By July 27, 2017

Data from the analysis showed a 73% mean reduction in diarrhea episodes from baseline after treatment with Mytesi for 24 weeks.

Updated Prescribing Information for ChiRhoStim

By July 25, 2017

ChiRhoStim is available as 16mcg and 40mcg strength lyophilized powder in single-dose vials for reconstitution.

Irritable Bowel Syndrome Treatments

July 25, 2017

Drug therapy for the treatment of irritable bowel syndrome (IBS).

Biosimilar Renflexis Now Available

July 24, 2017

Infliximab products work by neutralizing the biological activity of TNF-alpha by binding with high affinity to the soluble and transmembrane forms of TNF-alpha and inhibiting the binding of TNF-alpha with its receptors.

FDA Expands Use of RELiZORB to Include Children

By July 20, 2017

In the study, authors measured plasma omega-3 fatty acid concentrations as markers of fat absorption. Safety and tolerability were assessed by documentation of gastrointestinal (GI) symptoms.

Study Aims to "Set the Record Straight" on PPIs and Dementia

By July 20, 2017

After multivariable adjustment - which included duration of chronic medical conditions - a modest statistically significant association was only seen for psychomotor speed and attention.

Patient Develops Acute Liver Failure Following Amiodarone Infusion

July 19, 2017

The researchers describe a 79-year-old woman who was admitted with atrial flutter and treated with intravenous (IV) amiodarone. She developed coagulopathy, altered mental status, and derangement of liver enzymes.

Guidance Document Revises Management Practices in NAFLD

July 19, 2017

Pharmacologic treatments aimed at improving liver disease should be limited to those with biopsy-proven nonalcoholic liver steatohepatitis (NASH) and fibrosis.

How Common Is EPI in Patients with Chronic Abdominal Pain, Diarrhea?

By July 17, 2017

Overall, pancreatic exocrine insufficiency was identified in 10 patients (4.6%; 95% CI 2.2-8.3%) with five patients having severe pancreatic exocrine insufficiency (2.3%; 95% CI 0.8-5.3%).

Delayed-Release Pancreatic Enzyme Product Approved for G-Tube Administration

By July 14, 2017

The Pertzye labeling describes the required steps for administering the 4,000 lipase units capsule through the G-tube. Only the contents of the 4,000 lipase units capsule should be used for G-tube administration and no more than two capsules should be administered at a time.

Bismuth-Based Quad Tx Compared to Levofloxacin Triple Tx for <i>H. pylori</i> Infection

July 14, 2017

Addition of bismuth subcitrate to levofloxacin-based triple tx no more effective for H. pylori infection

Value of Enhanced Recovery Protocol in Colon, Rectal Sx

July 11, 2017

Based on one retrospective review of 8 years of compliance, the strongest predictors of shorter length of stay were identified as no nasogastric tube, early mobilization, early oral nutrition, early removal of epidural and urinary catheter, and nonopioid analgesia.

No Signs of Abuse Potential with Eluxadoline in IBS-D

July 10, 2017

The researchers found that there was no significant difference between the groups in terms of adverse events potentially related to abuse (2.8, 2.7, and 4.3%, respectively, for those given placebo, eluxadoline 75mg, or eluxadoline 100mg)

Proton Pump Inhibitor Use May Up Death Risk

By July 05, 2017

The authors found that compared to the use of H2RA therapy, patients initiated on PPI therapy had a 25% increased risk of death (hazard ratio [HR] 1.25, 95% CI: 1.23-1.28).

New FDA Policy Aims to Increase Number of Generics on Market

By June 29, 2017

"No patient should be priced out of the medicines they need, and as an agency dedicated to promoting public health, we must do our part to help patients get access to the treatments they require," said FDA Commissioner Scott Gottlieb, MD.

Do PPIs Increase the Risk of Dementia?

By June 22, 2017

The data indicated continuous PPI use was tied to a reduced risk of cognitive function decline vs. never use (hazard ratio [HR] 0.78, 95% CI: 0.66-0.93; P=0.005).

Nephron Pharma Responds to Sodium Bicarbonate Shortage

By June 22, 2017

Nephron Pharmaceuticals has joined the effort to abate the nationwide shortage of Sodium Bicarbonate 8.4% by tripling its production of the injectable syringes.

Task Force Issues New CRC Screening Recommendations

By June 21, 2017

Individuals with a family history of CRC in a first-degree relative diagnosed before age 60 should undergo colonoscopy every 5 years beginning at age 40 or 10 years before the age at which their relative was diagnosed.