Gastrohepatic Disorders

Treatment for Alagille Syndrome Granted Orphan Drug Designation

By October 17, 2018

Alagille syndrome affects approximately 1 in 70,000 newborns.

Novel Blood Test for Irritable Bowel Syndrome Now Available

By October 10, 2018

The test works by measuring levels of anti-cytolethal distending toxin B (CdtB) and anti-vinculin, 2 biomarkers of post-infectious IBS-D and IBS-M.

Ustekinumab Induces Clinical Remission After One Dose in Ulcerative Colitis Study

By October 10, 2018

Study authors at the American College of Gastroenterology (ACG) Scientific Meeting 2018 presented late-breaking data from the induction phase of the Phase 3 UNIFI study.

GERD Diagnosis and Management Guidelines

By October 09, 2018

Expert recommendations for the diagnosis and management of gastroesophageal reflux disease (GERD).

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

By October 09, 2018

The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.

Probiotic Use May Not Protect Against <i>Clostridium Difficile</i> Infection

October 05, 2018

In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection

Sucraid Supply Restored for Patients With Genetic Sucrase-Isomaltase Deficiency

By October 02, 2018

The Company stated that they are now able to meet all prescription demands for Sucraid without informed consent.

Proton Pump Inhibitor Use Tied to Hip Fracture in Dialysis Patients

September 28, 2018

The researchers found that a larger proportion of cases than controls had prior PPI use (70 vs 63%) or histamine-2 receptor antagonist use (25 vs 23%).

Irritable Bowel Syndrome Treatments

September 27, 2018

Drug therapy for the treatment of irritable bowel syndrome (IBS).

Antiemetic Treatments

September 26, 2018

Antiemetic treatment chart including drug formulations, strengths, and usual doses for nausea/vomiting.

Reflux Band Now Available OTC for Reducing Laryngopharyngeal Reflux

By September 26, 2018

In one study, 86% of patients clinically diagnosed with esophagopharyngeal reflux reported significant reduction in symptoms after 2 weeks of use.

Irritable Bowel Syndrome Evaluation

September 26, 2018

Irritable Bowel Syndrome (IBS) evaluation chart based on Manning Criteria and Rome III Diagnostic Criteria.

Antibiotic Tx Appears to Be a Reasonable Option for Uncomplicated Acute Appendicitis

By September 26, 2018

The study included 530 patients, aged 18 to 60 years, with computed tomography-confirmed uncomplicated acute appendicitis.

On-Demand PPI Use Examined in Non-Erosive Reflux Disease, Mild Erosive Esophagitis

By September 20, 2018

Results of the study found on-demand PPI use to be superior to daily administration of a PPI (pooled OR: 0.50; 95% CI: 0.35, 0.72).

Infant PPI Use and Lung Infection Risk: Is There a Link?

By September 20, 2018

The data showed matched odds ratio for current vs past use of PPIs to be 0.88 (95% CI, 0.36 to 2.16) when comparing cases and their controls for community-acquired pneumonia. With regard to lower respiratory tract infections, the matched odds ratio between cases and their controls was 1.13 (95% CI, 0.87 to 1.48).

Tenapanor NDA Submitted for Irritable Bowel Syndrome With Constipation

By September 14, 2018

Tenapanor, a minimally-systemic small molecule, inhibits the sodium transporter NHE3 and reduces sodium absorption in the gastrointestinal tract, thus increasing intestinal fluid.

Out-of-Pocket Costs Similar for Infliximab, Infliximab-Dyyb

September 05, 2018

"Although biosimilar gap discounts begin in 2019, infliximab-dyyb may still not significantly reduce Part D beneficiaries' out-of-pocket costs given its high price and coinsurance cost-sharing similar to infliximab," the authors write.

FDA Warns of Dangers of Liquid Nitrogen in Food, Drinks

September 04, 2018

Liquid nitrogen isn't toxic, but its extremely low temperature can cause severe damage to skin and internal organs if mishandled or consumed, the FDA said in a news release.

Drinking Water Turned Off in All Detroit's Public Schools

August 31, 2018

Recent tests revealed "higher than acceptable levels... (of) copper and/or lead" in at least 1 water source - such as a fountain or sink - at 16 of 24 schools, Vitti said.

Secretagogues Compared in Irritable Bowel Syndrome With Constipation

By August 29, 2018

While several secretagogues have been recently approved by the Food and Drug Administration (FDA), a lack of head-to-head trials led researchers to conduct a systematic review to compare the effectiveness of these agents in patients with IBS-C.

Odds of Marijuana Use Up With Nausea, Vomiting in Pregnancy

August 27, 2018

The prevalence of prenatal marijuana use was 5.3% by self-report or toxicologic test findings; prevalence was greater among females with severe and mild versus no NVP (11.3 and 8.4, respectively, vs 4.5%).

Long-Term PPI Use Linked to Pneumonia Risk in Older Adults

August 24, 2018

Rate of incident pneumonia increased in second year after initiating treatment with proton pump inhibitors

Treatments for Primary Prevention of Esophageal Variceal Bleeding Compared

By August 22, 2018

Treatments (NSBB, isosorbide mononitrate, carvedilol, variceal band ligation) were compared as monotherapy or as combination therapy with each other or versus placebo.

Lenvima OK'd as First-Line Treatment for Unresectable Hepatocellular Carcinoma

By August 16, 2018

The approval was supported by findings from the multicenter, randomized, open-label, noninferiority trial, REFLECT (N=945), which included patients with previously untreated, metastatic or unresectable HCC.

FDA to Review Gimoti for Diabetic Gastroparesis in Adult Women

By August 16, 2018

The FDA has set a Prescription Drug User Fee Act target date of April 1, 2019.

Anti-MAP Therapy Beneficial in Phase 3 Crohn's Disease Trial

By August 01, 2018

The randomized, double-blind, placebo-controlled study (N=331) achieved its primary endpoint and key secondary endpoints in the intent-to-treat (ITT) population.

Iron Therapies Compared in Patients With GI-Related Iron Deficiency Anemia

By July 30, 2018

The analysis also showed that the more severe the anemia was at baseline, the greater the response was to treatment with regard to hemoglobin changes.

Coffee Consumption and Pancreatitis Risk: What's the Link?

By July 27, 2018

For this meta-analysis, researchers searched for case-control, cross-sectional, or cohort studies that included keywords such as "coffee", "caffeine", and "pancreatitis" and compared the risk of pancreatitis based on coffee consumption.

Vedolizumab SC Induces Clinical Remission in Phase 3 Ulcerative Colitis Study

By July 23, 2018

The study included 384 adult patients with moderately to severely active UC who had an inadequate response with, loss of response to, or intolerance to corticosteroids, immunomodulators, or tumor necrosis factor-alpha (TNFα)-antagonist therapy prior to being enrolled.

Opdivo + Yervoy Approved to Treat MSI-H/dMMR Metastatic Colorectal Cancer

By July 12, 2018

The approval was based on data from the ongoing Phase 2 CheckMate-142 study which enrolled patients with MSI-H/dMMR metastatic CRC who had received ≥1 prior line of therapy for metastatic disease (N=119).