Gastrohepatic Disorders

IBD and Anemia: Adverse Events After IV Iron Therapy Examined

By April 23, 2018

To examine the occurrence of adverse reactions in this patient population, researchers from John Hopkins University, Baltimore, Maryland, conducted a retrospective analysis of IBD patients who received IV iron infusions between 2010 and 2014 in the commercial claims database, MarketScan.

FDA Approves New Formulation of Akynzeo for CINV

By April 20, 2018

Akynzeo IV combines fosnetupitant (prodrug of netupitant), a substance P/NK1 receptor antagonist, and palonosetron, a 5-HT3 receptor antagonist.

GI Safety Compared for NSAIDs in Patients With Arthritis

By April 19, 2018

The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Optimizing organ donations from overdose deaths may help address national organ shortage

April 19, 2018

U.S. transplants using organs from overdose-death donors (ODDs) has increased 24-fold from 2000 to 2016, and transplant outcomes from organs donated by ODDs have been noninferior to those donated by trauma-death donors (TDDs) and medical-death donors (MDDs).

Opiate Use Linked to Early Mortality in IBD Patients

April 18, 2018

Heavy use in Crohn's, heavy or moderate use in ulcerative colitis tied to increased risk of death

<i>C. Difficile</i> Risk Higher With Stoma Reversal vs Difficile

April 18, 2018

Factors associated with C. difficile infection incidence in the 30-day postoperative period after controlling for other variables include stoma reversal (odds ratio, 2.701; P<.001), smoking (odds ratio, 1.520; P<.022), steroids (odds ratio, 1.677; P<.048), and disseminated cancer.

Long-Term Obeticholic Acid Linked to Fibrosis Regression in PBC Patients

By April 13, 2018

Results showed that 46% (n=6) of substudy patients improved their histological fibrosis stage, while 38% maintained (n=5), and 15% experienced 1 stage progression (n=2).

Iron Formulation and Cancer Risk: Is There a Link?

By April 12, 2018

In the U.S., ferric citrate is commonly found in dietary supplements and ferric EDTA is often used as a food additive.

OTC Heartburn Treatment Available in New Orally Disintegrating Tablets

By April 11, 2018

Omeprazole ODT utilizes MelTech technology that allows the tablet to dissolve in the mouth without water.

Acid suppression and antibiotic use in infancy linked to allergic disease

April 11, 2018

Use of histamine 2 receptor antagonists (H2RA) or proton pump inhibitors (PPIs) during the first 6 months of life was associated with increased risk of allergic disease and asthma.

DPP-4I Not Tied to Increased Risk of Acute Pancreatitis in Seniors

April 10, 2018

The researchers found that the risk of acute pancreatitis was not increased comparing 49,374 DPP-4I initiators with 132,223 sulfonylurea initiators and comparing 57,301 DPP-4I initiators with 32,612 thiazolidinedione initiators.

Oral Nitroglycerin Solution: An Effective Option for Esophageal Food Impaction?

By April 09, 2018

While glucagon is often used for the treatment of esophageal food impaction, its effectivess, based on several studies, has been inconsistent.

Obesity Can Negatively Affect Liver in Children As Young As 8

April 06, 2018

Each additional 10cm greater waist circumference at early childhood was associated with 1.99 higher odds of elevated ALT at mid-childhood, in multivariable-adjusted models.

"Condom Challenge" Growing in Popularity Among Teens

By April 03, 2018

"As graphic as it is, we have to show parents because teens are going online looking for challenges and recreating them," said education specialist Stephen Enriquez.

Antibiotics, Acid-Suppressive Meds Tied to Allergic Disease

April 03, 2018

The researchers found that 7.6% of included children were prescribed a histamine-2 receptor antagonist (H2RA), 1.7 percent a proton pump inhibitor (PPI), and 16.6% an antibiotic during the first 6 months of life.

Firvanq Availability Replaces Need for Compounded Oral Vancomycin Solution

By April 02, 2018

Firvanq will replace CutisPharma's FIRST-Vancomycin Unit-of-Use Compounding Kit.

Bonjesta Now Available to Treat Nausea and Vomiting of Pregnancy

By April 02, 2018

Bonjesta is a multilayer, extended-release formulation that is designed to provide both fast-acting and long-lasting symptom relief.

Livantra Granted Orphan Drug Status for Acute-on-Chronic Liver Failure

By March 30, 2018

Livantra may help rate of survival without transplantation or help improve survival until patients can receive a new liver.

Wearable System Provides 24-Hour Ambulatory GI Monitoring

By March 22, 2018

The wearable system was found to work as well as more invasive methods.

Cimzia Label Update Provides New Information for Women of Childbearing Age

By March 22, 2018

Data added to the labeling includes first-of-their-kind pharmacokinetic studies demonstrating negligible to low transfer of CIMZIA through placenta and minimal transfer to breast milk from mother to infant.

DPP-4 Inhibitors and Inflammatory Bowel Disease Risk: Is There a Link?

March 22, 2018

This first population-based study, found that DPP-4 inhibitors were associated with an increased risk of inflammatory bowel disease.

H. pylori Infection Treatment Guideline

March 22, 2018

Recommendations from the ACG Clinical Guideline for the treatment of H. pylori infection.

Liver Disease, Insulin Resistance Associated With High Red Meat Consumption

March 20, 2018

The researchers found that after adjusting for body mass index, physical activity, smoking, alcohol, energy, saturated fat and cholesterol intake, the odds of NAFLD and IR were increased in association with high consumption of total meat.

Does Gut Bacteria Translocate to the Brain During Sepsis?

March 15, 2018

Among humans who died of sepsis, bacterial taxa detected in their brains were distinct from those who died of noninfectious causes and were correlated with S100A8/A9 expression.

FDA Clears New <i>H. pylori</i> Testing Option for Pediatric Patients

By March 13, 2018

The result comparisons found an overall agreement in the pre-therapy cohort between the breath test and the reference biopsy result of 98.3% (95 CI: 95.2%-99.7%).

Sollpura Falls Short in Exocrine Pancreatic Insufficiency Trial

By March 13, 2018

the Phase 3 'SOLUTION' study of Sollpura did not meet the primary endpoint of non-inferiority to an active-comparator in the coefficient of fat absorption (CFA).

Xeljanz Gets FDA Committee Nod for Ulcerative Colitis Indication

By March 09, 2018

The GIDAC recommendations are provided to the FDA but they are not binding. The FDA has set a target PDUFA action date of June 2018.

FDA Accepts NDA for Novel Chronic Idiopathic Constipation Treatment

By March 05, 2018

If approved, prucalopride will be the only readily available 5-HT4 agonist for adult CIC in the U.S.

Pancreatic Enzyme Replacement Therapy

March 02, 2018

Pancreatic enzyme (lipase, pancrease, amylase) replacement therapy comparison chart.

Limited Data on Combination Biologic Therapy for IBD, Says Study

By February 28, 2018

The authors point out how, unlike other autoinflammatory conditions, "IBD has the benefit of effective and safe gut specific anti-integrin therapies which can provide a platform off of which combinations can be employed."