Generic Name and Formulations:
Nitrofurantoin 25mg/5mL; susp.
Company:
Shionogi, Inc.
Susceptible UTIs.
Take with food. 50–100mg 4 times daily. Suppressive therapy: 50–100mg once daily at bedtime may suffice.
Take with food. <1month: contraindicated. ≥1month: 5–7mg/kg per day in 4 divided doses. Suppressive therapy: 1mg/kg per day in 1–2 divided doses may suffice.
Antibiotic.
Renal impairment (CrCl <60mL/min, anuria, oliguria, or significantly elevated serum creatinine). Neonates. Labor & delivery. Pregnancy at term.
Renal insufficiency. G6PD or Vit. B deficiency. Anemia. Diabetes. Electrolyte imbalance. Asthma. Debilitated. Discontinue if pulmonary or hepatic disorders, hemolysis, or peripheral neuropathy occurs. Monitor renal and pulmonary function in long-term use. Pregnancy (Cat.B). Nursing mothers: not recommended.
Avoid magnesium trisilicate. Antagonized by, and increased toxicity with uricosurics (eg, probenecid). May cause false (+) glucose test with Benedict's or Fehling's solution.
GI upset, dizziness, headache, pulmonary or hematological disorders (esp. in long-term use), peripheral neuropathy; rare: hepatic dysfunction, exfoliative dermatitis, Stevens-Johnson syndrome, optic neuritis, methemoglobinemia.
Susp—60mL, 470mL