Generic Name and Formulations:
Fluticasone propionate 44mcg/inh, 110mcg/inh, 220mcg/inh; metered dose inhaler; CFC-free.
Company:
GlaxoSmithKline Pharmaceuticals
Maintenance treatment of asthma as prophylactic therapy. Asthma requiring systemic corticosteroid therapy, to reduce need for oral systemic corticosteroids.
Previously on bronchodilators alone: initially 88mcg twice daily; max 440mcg twice daily. Previously on inhaled corticosteroids: initially 88–220mcg twice daily; max 440mcg twice daily. Previously on oral corticosteroids (wean gradually): initially 440mcg twice daily; max 880mcg twice daily. Rinse mouth after use.
<4yrs: not recommended. 4–11yrs: 88mcg twice daily. Rinse mouth after use.
Steroid.
Not for primary treatment of acute attack.
Maintain regular regimen. Infections. If exposed to chickenpox or measles, consider anti-infective prophylactic therapy. If adrenal insufficiency exists following systemic corticosteroid therapy, replacement with inhaled corticosteroids may exacerbate symptoms of adrenal insufficiency (eg, lassitude). Monitor for growth suppression in children. Monitor for hypercorticism and HPA axis suppression (if occur discontinue gradually). Hepatic impairment (monitor). Transferring from oral corticosteroids: see literature. Pregnancy (Cat.C). Nursing mothers.
Avoid ritonavir. Caution with potent CYP3A4 inhibitors (eg, ketoconazole).
Local effects (pharyngitis, nasal congestion/discharge, rhinitis, dysphonia, sinusitis, oral candidiasis), upper respiratory infection, headache, influenza, bronchospasm.
Inhaler w. actuator (44mcg)—10.6g (120 inh); 110mcg, 220mcg—12g (120 inh)