Maintenance treatment of asthma as prophylactic therapy. Asthma requiring systemic corticosteroid therapy, to reduce need for oral systemic corticosteroids.
≥11yrs: Previously on bronchodilators alone: initially 100mcg twice daily; max 500mcg twice daily. Previously on inhaled corticosteroids: initially 100–250mcg twice daily; max 500mcg twice daily. Previously on oral corticosteroids (wean gradually): initially 500–1000mcg twice daily; max 1000mcg twice daily. Rinse mouth after use.
<4yrs: not recommended. 4–11yrs: Previously on bronchodilators alone or on inhaled corticosteroids: initially 50mcg twice daily; max 100mcg twice daily. Rinse mouth after use.
Not for primary treatment of acute attack.
Maintain regular regimen. Infections. If exposed to chickenpox or measles, consider anti-infective prophylactic therapy. If adrenal insufficiency exists following systemic corticosteroid therapy, replacement with inhaled corticosteroids may exacerbate symptoms of adrenal insufficiency (eg, lassitude). Monitor for growth suppression in children. Monitor for hypercorticism and HPA axis suppression (if occur discontinue gradually). Hepatic impairment (monitor). Transferring from oral corticosteroids: see literature. Pregnancy (Cat.C). Nursing mothers.
Avoid ritonavir. Caution with potent CYP3A4 inhibitors (eg, ketoconazole).
Local effects (pharyngitis, nasal congestion/discharge, rhinitis, dysphonia, sinusitis, oral candidiasis), upper respiratory infection, headache, influenza, bronchospasm.
Diskus (60 blisters)—1