Tension (or muscle contraction) headache.
1–2 caps every 4 hours as needed; max 6/day.
Barbiturate + analgesic.
Porphyria. Also with Codeine: post-op pain management in children who have undergone tonsillectomy and/or adenoidectomy.
Hepatotoxicity (acetaminophen >4g/day). Drug abusers. Impaired hepatic or renal function (monitor). Acute abdomen. Depression. Suicidal tendencies. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended. Also with Codeine: risk of respiratory depression and death related to ultra-rapid metabolizers of codeine (esp. in children in post-op tonsillectomy and/or adenoidectomy). Obstructive sleep apnea. Head injury. Increased intracranial pressure. Impaired thyroid or adrenocortical function. GI or GU obstruction. Addison's disease. Labor and delivery.
Potentiation with alcohol, general anesthetics, MAOIs, tranquilizers, or other CNS depressants. Induction of drug-metabolizing hepatic enzymes. Acetaminophen may cause false (+) urine test for 5-hydroxyindoleacetic acid.
Drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, abdominal pain, intoxicated feeling, depression, confusion, paradoxical excitement, abuse potential, skin reactions; overdosage: respiratory depression, hepatotoxicity.