FDA-APPROVED PROSTATE CANCER TREATMENTS
 
Generic & Class Brand & Company Strength Form Usual Dose*
Alkylating agent
estramustine Emcyt
(Pfizer)		 140mg caps 14mg/kg in 3 or 4 divided doses
Antiandrogens
bicalutamide Casodex
(AstraZeneca)		 50mg tabs 50mg daily
flutamide (various) 125mg caps 250mg every 8 hrs
nilutamide Nilandron
(Sanofi Aventis)		 150mg tabs 300mg once daily for 30 days, then 150mg once daily, starting day of or day after surgical castration
Antimicrotubule agents
docetaxel Taxotere
(Sanofi Aventis)		 40mg/mL soln for IV infusion after dilution 75mg/m2 once every 3 weeks
cabazitaxel Jevtana
(Sanofi Aventis)		 60mg/1.5mL soln for IV infusion after dilution 25mg/m2 once every 3 weeks with oral prednisone 10mg daily during treatment
Antineoplastic agent
abiraterone acetate Zytiga
(Janssen)		 250mg tabs 1g once daily (in combination with prednisone 5mg twice daily) on an empty stomach
Estrogens
estradiol Estrace
(Warner Chilcott)		 0.5mg, 1mg, 2mg scored tabs 1–2mg 3 times daily
estrogens, esterified Menest
(King)		 0.3mg, 0.625mg, 1.25mg, 2.5mg tabs 1.25–2.5mg 3 times daily
GnRH analogues
goserelin acetate Zoladex
(AstraZeneca)		 3.6mg SC implant Advanced prostate cancer: one 3.6mg implant every 28 days or one 10.8mg implant every 12 weeks Stage B2-C prostatic carcinoma (in combination with flutamide): Initially one 3.6mg implant, followed in 28 days by one 10.8mg implant; or may use one 3.6mg implant every 28 days. Treat 8 weeks prior to and during radiotherapy.
Zoladex 3-Month 10.8mg
(AstraZeneca)		 10.8mg
histrelin acetate Vantas
(Endo)		 50mg SC implant Insert 1 implant SC in the inner aspect of the upper arm; remove or replace after 12 months
leuprolide acetate Eligard 7.5mg 1-month
(Sanofi Aventis)		 7.5mg ext-rel susp for SC inj 7.5mg SC once per month; or 22.5mg SC once every 3 months; or 30mg SC once every 4 months; or 45mg SC once every 6 months
Eligard 22.5mg 3-month
(Sanofi Aventis)		 22.5mg
Eligard 30mg 4-month
(Sanofi Aventis)		 30mg
Eligard 45mg 6-month
(Sanofi Aventis)		 45mg
leuprolide acetate Lupron Depot 7.5mg
(Abbott)		 7.5mg depot susp for IM inj 7.5mg once a month
Lupron Depot–3month 22.5mg
(Abbott)		 22.5mg 22.5mg every 3 months (84 days). Do not split doses.
Lupron Depot–4month 30mg
(Abbott)		 30mg 30mg as single dose every 4 months (16 weeks). Do not split doses.
Lupron Depot - 6month 45mg
(Abbott)		 45mg 45mg as a single dose every 6 months (24 weeks). Do not split doses.
triptorelin pamoate Trelstar
(Watson)		 3.75mg, 11.25mg, 22.5mg pwd for IM inj after reconstitution 3.75mg every 4 weeks or 11.25mg every 12 weeks or 22.5mg every 24 weeks
GnRH antagonist
degarelix Firmagon
(Ferring)		 80mg/vial, 120mg/vial pwd for SC inj after reconstitution Give by SC inj in abdomen once every 28 days; avoid waist and rib areas. Two 120mg injections once, then one 80mg inj once every 28 days.
NOTES

* For more detailed dosing information, see drug entry.

(Rev. 10/2011)