FDA-APPROVED OVARIAN CANCER TREATMENTS
 
Generic & Class Brand & Company Strength Form Usual Dose*
Alkylating agent
Altretamine Hexalen
(MGI Pharma)

 

 50mg caps 260mg/m2 daily in four divided doses for either 14 or 21 consecutive days in a 28 day cycle 

 
Carboplatin Paraplatin
(Bristol Myers Squibb)		 10mg/mL soln for IV infusion Advanced ovarian cancer (previously untreated): 300mg/m2 on Day 1 every 4 weeks for 6 cycles 
Recurrent ovarian cancer: 360mg/m2 on Day 1 every 4 weeks 

 
Cisplatin

 

 (various) 1mg/mL soln for IV infusion after dilution 100mg/m2 once every 4 weeks
Cyclophosphamide (various) 25mg, 50mg tabs 1–5mg/kg/day
Cytoxan injection
(Bristol Myers Squibb)		 500mg, 1g, 2g pwd for inj after reconstitution 40–50mg/kg in divided doses over 2–5 days or 10–15mg/kg every 7–10 days or 3–5mg/kg twice weekly
Melphalan Alkeran
(GlaxoSmithKline)		 2mg scored tabs 0.2mg/kg/day for 5 days; repeat every 4–5 weeks
Thiotepa (various) 15mg, 30mg pwd for IV, intravesical, or intracavitary administration after reconstitution 0.3–0.4mg/kg IV once every 1–4 weeks
Antibiotics (cytotoxic)
Doxorubicin Adriamycin
(Bedford)		 10mg, 20mg, 50mg pwd for IV inj after reconstitution Monotherapy: 60–75mg/m2 every 21 days 
Combination therapy: 40–60mg/m2 every 21 to 28 days 
Adriamycin Solution
(Bedford)		 2mg/mL soln for IV inj
Doxorubicin (liposomal) Doxil
(Ortho Biotech)		 2mg/mL dispersion for IV infusion after dilution 50mg/m2 once every 4 weeks
Antimetabolite
Gemcitabine Gemzar
(Lilly)		 200mg, 1g pwd for IV infusion after reconstitution 1000mg/m2 on Days 1 and 8 of each 21 day cycle 
Hydroxyurea Hydrea
(Bristol Myers Squibb)		 500mg caps Intermittant therapy: 80mg/kg as single dose every 3rd day
Continuous therapy: 20–30mg/kg/day as single dose
Antimicrotubule agents
Paclitaxel Taxol
(Bristol Myers Squibb)		 6mg/mL soln for IV administration after dilution Previously untreated ovarian cancer: 175mg/m2 over 3 hours or 135mg/m2 over 24 hours; repeat every 3 weeks 
Previously treated ovarian cancer: 135mg/m2 or 175mg/m2 over 3 hours every 3 weeks 

 
NOTES

* For more detailed dosing information, see drug entry.

(Rev. 10/2009)