FDA-APPROVED COLORECTAL CANCER TREATMENTS
 
Generic & Class Brand & Company Strength Form Usual Dose*
Alkylating agents
Oxaliplatin Eloxatin (Sanofi Aventis) 5mg/mL soln for IV infusion after dilution Day 1: 85mg/m2 + leucovorin, followed by 5–FU.
Day 2: Leucovorin followed by 5–FU.
Give by IV infusion every two weeks for a total of 6 months (eg, 12 cycles).
Antimetabolites
Capecitabine Xeloda (Roche) 150mg, 500mg tabs 1250mg/m2 twice daily for a total of 8 cycles
Fluorouracil (various) 50mg/mL soln for IV inj 12mg/kg once daily for 4 successive days; max 800mg/day
Folic acid derivative
Leucovorin Leucovorin (Teva) 100mg, 350mg lyophilized pwd for IV or IM inj reconstitution 200mg/m2 by slow IV inj followed by 5–fluorouracil (370mg/m2); or 20mg/m2 IV followed by 5 fluorouracil (425mg/m2); both regimens: daily for 5 days, may be repeated at 4 week intervals for 2 courses and then repeated at 4–5 week intervals
Monoclonal antibodies
Bevacizumab Avastin (Genentech) 100mg, 400mg soln for IV infusion after dilution 5mg/kg (with bolus–IFL) or 10mg/kg (with FOLFOX–4) once every 14 days until disease progression detected
Cetuximab Erbitux (Bristol Myers Squibb) 100mg, 200mg soln for IV infusion Loading dose: 400mg/m2 once over 2 hours; then 250mg/m2 once weekly over 1 hour
Panitumumab Vectibix (Amgen) 20mg/mL soln for IV infusion after dilution 6mg/kg once every 14 days until disease progression detected
Topoisomerase inhibitors
Irinotecan Camptosar (Pfizer) 20mg/mL soln for IV infusion after dilution Combination therapy: 125mg/m2 on days 1, 8, 15, 22; or, 180mg/m2 on days 1, 15, 29; both: give every 6 weeks.
Monotherapy: 125mg/m2 on days 1, 8, 15, 22, then 2–week rest; or, 350mg/m2 once every 3 weeks.
NOTES

*For more detailed dosing information, see drug entry.

(Rev. 3/2012)