FDA-APPROVED BREAST CANCER TREATMENTS
 
Generic & Class Brand & Company Strength Form Usual Dose*
Alkylating Agents
cyclophosphamide Cytoxan injection (Bristol Myers Squibb) 500mg, 1g, 2g pwd for IV inj after reconstitution 40–50mg/kg in divided doses over 2–5 days or 10–15mg/kg every 7–10 days or 3–5mg/kg twice weekly
(various) 25mg, 50mg tabs 1–5mg/kg/day
thiotepa (various) 15mg, 30mg pwd for IV, intravesical, or intracavitary administration after reconstitution 0.3–0.4mg/kg IV once every 1–4 weeks
Angiogenesis Inhibitor
bevacizumab Avastin (Genentech) 100mg, 400mg soln for IV infusion after dilution 10mg/kg once every 14 days
Antibiotics (Cytotoxic)
doxorubicin Adriamycin (Bedford) 10mg, 20mg, 50mg pwd for IV inj after reconstitution Monotherapy: 60–75mg/m2 every 21 days Combination therapy: 40–60mg/m2 every 21 to 28 days
Adriamycin Solution (Bedford) 2mg/mL soln for IV inj
epirubicin Ellence (Pfizer) 2mg/mL soln for IV infusion 100–120mg/m2 on Day 1 or divided equally given on Days 1 and 8 of each cycle
Antiestrogen
tamoxifen (various) 10mg, 20mg tabs 20–40mg/day
Soltamox Oral Solution (Savient) 10mg/5mL oral soln
toremifene Fareston (GTx) 60mg tabs 60mg once daily
Antimetabolites
capecitabine Xeloda (Roche) 150mg, 500mg tabs Monotherapy: 1250mg/m2 twice daily Combination therapy: give with docetaxel 75mg/m2 IV infused over 1 hour every 3 weeks.
fluorouracil (various) 50mg/mL soln for IV inj 12mg/kg once daily for 4 successive days; max 800mg/day
gemcitabine Gemzar (Lilly) 200mg, 1g pwd for IV infusion after reconstitution 1250mg/m2 on Days 1 and 8 of each 21 day cycle
methotrexate Methotrexate injection (Bedford) 25mg/mL soln for IV, IM, intra-arterial, or intra-thecal administration after dilution See drug entry and manufacturer's literature
1g pwd for IV, IM, intra-arterial, or intra-thecal administration after dilution
Trexall (Duramed) 5mg, 7.5mg, 10mg, 15mg scored tabs
Antimicrotubule Agents
docetaxel Taxotere (Sanofi Aventis) 40mg/mL soln for IV infusion after dilution 60–100mg/m2 once every 3 weeks
eribulin mesylate Halaven (Eisai) 0.5mg/mL soln for IV inj 1.4mg/m2 IV inj over 2–5min on Days 1 and 8 of each 21 day cycle.
ixabepilone Ixempra (Bristol Myers Squibb) 15mg, 45mg pwd for IV infusion after constitution and dilution 40mg/m2 once every 3 weeks
paclitaxel Abraxane (Abraxis) 100mg IV infusion; inj susp after reconstiution 260mg/m2 every 3 weeks
Taxol (Bristol Myers Squibb) 6mg/mL soln for IV infusion after dilution 175mg/m2 every 3 weeks
vinblastine for injection (Bedford) 10mg lyophilized pwd for IV inj or infusion after reconstitution 5.5–7.4mg/m2 once weekly (see literature)
vinblastine injection (APP Pharmaceuticals) 1mg/mL soln for IV inj or infusion
Aromatase Inhibitor
anastrozole Arimidex (AstraZeneca) 1mg tabs 1mg once daily
exemestane Aromasin (Pfizer) 25mg tabs 25mg once daily
letrozole Femara (Novartis) 2.5mg tabs 2.5mg once daily
Estrogen
estradiol Estrace (Warner Chilcott) 0.5mg, 1mg, 2mg scored tabs 10mg 3 times daily for at least 3 months
Estrogen Receptor Antagonist
fulvestrant Faslodex (AstraZeneca) 50mg/mL soln for IM inj 500mg on days 1, 15, 29, then once per month thereafter
GnRH Analogue
goserelin Zoladex (AstraZeneca) 3.6mg SC implant one 3.6mg implant every 28 days
Human Epidermal Growth Factor Receptor (HER2) inhibitor
trastuzumab Herceptin (Genentech) 440mg lyophilized pwd for IV infusion after reconstitution and dilution See drug entry
Progestin
megestrol acetate Megace (Bristol Myers Squibb) 20mg, 40mg scored tabs 40mg 4 times daily
Selective Estrogen Receptor Modulator (SERM)
raloxifene Evista (Lilly) 60mg tabs 60mg once daily
Tyrosine Kinase Inhibitor
lapatinib Tykerb (GlaxoSmithKline) 250mg tabs See drug entry and manufacturer's literature
NOTES

* For more detailed dosing information, see drug entry.

(Rev. 12/2011)