FACTIVE
Generic Name for FACTIVE
Gemifloxacin mesylate 320mg; scored tabs.
Legal Classification:
Rx
Pharmacological Class for FACTIVE
Quinolone.
Manufacturer of FACTIVE
Oscient Pharmaceuticals
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Indications for FACTIVE
Susceptible infections including acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia.
Adult dose for FACTIVE
≥18yrs: Swallow whole. Take with full glass of water. 320mg once daily. Bronchitis: treat for 5 days. Community-acquired pneumonia: treat for 5 or 7 days (based on susceptible bacteria; see literature). Renal impairment and dialysis: CrCl≤40mL/min: 160mg every 24 hours.
Children's dosing for FACTIVE
<18yrs: not recommended.
Warnings/Precautions for FACTIVE
Increased risk of tendinitis and tendon rupture esp. in patients >60yrs, or those with kidney, heart or lung transplants. Maintain adequate hydration. Discontinue if rash, other signs of hypersensitivity, phototoxicity, CNS stimulation, or tendon pain, inflammation, or rupture occurs. CNS disorders (eg, epilepsy). Avoid sunlight, UV light. History of QTc prolongation, electrolyte disorders (eg, hypokalemia), or proarrhythmic conditions. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for FACTIVE
Avoid drugs that prolong QTc interval (eg, Class IA or Class III antiarrhythmics, erythromycin, antipsychotics, tricyclics). Separate dosing of magnesium- or aluminum containing antacids and didanosine, sucralfate, iron, zinc, other metal cations (do not take within 3 hours before or 2 hours after gemifloxacin). Potentiated by probenecid. Increased risk of tendinitis and tendon rupture with corticosteroids. Monitor warfarin.
Adverse Reactions for FACTIVE
GI upset, rash, urticaria, headache, abdominal pain, dizziness, elevated liver enzymes, photosensitivity, tendinitis/rupture; rarely: convulsions.
How is FACTIVE supplied?
Tabs—5, 7
Related Disease:
Bronchitis, chronic
Infections, bacterial~systemic antiinfectives
Pneumonia