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Multiple sclerosis
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Generic Name and Formulations:

Interferon beta-1b 0.3mg/vial; pwd for SC inj after reconstitution; contains albumin (human), mannitol.

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Indications for EXTAVIA:

To reduce frequency of clinical exacerbations in relapsing multiple sclerosis.


Pre-medicate with analgesics and/or antipyretics on treatment days to ameliorate flu-like symptoms. ≥18yrs: initially 0.0625mg SC every other day; increase by 25% every 2 weeks to target dose of 0.25mg SC every other day.


<18yrs: not established.


Monitor for signs/symptoms of hepatic injury; consider discontinuing if elevated transaminase levels or jaundice occurs. Depression. Suicidal ideation. Pre-existing CHF: monitor for worsening cardiac function at initiation and during treatment. Myelosuppression. Discontinue if thrombotic microangiopathy or signs/symptoms of drug-induced lupus erythematosus occurs. Monitor CBCs, differential, platelets, chemistries, liver function (at 1, 3, and 6 months then periodically). Pregnancy (Cat.C; may be abortifacient). Nursing mothers: not recommended.

Pharmacological Class:



Risk of hepatic injury with concomitant hepatotoxic drugs or other products (eg, alcohol).

Adverse Reactions:

Inj site reactions, lymphopenia, flu-like symptoms, myalgia, leukopenia, neutropenia, increased liver enzymes, headache, hypertonia, pain, rash, insomnia, abdominal pain, asthenia; inj site necrosis (suspend therapy if multiple lesions occur); rare: hepatic injury, anaphylaxis, possibly seizures.

How Supplied:

Single-use vials—15 (w. prefilled diluent syringe, supplies)