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Generic Name and Formulations:

Bupivacaine 13.3mg/mL; liposome injectable suspension; preservative-free.

Select therapeutic use:

Indications for EXPAREL:

For administration into the surgical site to produce postsurgical analgesia.


For single-dose administration only. Base dose on surgical site and volume required to cover area. Inject slowly into soft tissue via infiltration. Bunionectomy: 106mg (volume: 8mL). Hemorrhoidectomy: 266mg (volume: 20mL). Max dose: 266mg. See full labeling for administration.


<18yrs: not established.


Obstetrical paracervical block.


Not interchangeable with other forms of bupivacaine. Avoid intravascular, intra-articular, intrathecal, epidural, or regional nerve block inj. To be administered under the supervision of experienced clinicians. Cardiovascular disease. Hepatic or renal impairment. Monitor neurologic, cardiovascular and respiratory vital signs. Elderly. Pregnancy, nursing mothers: not recommended.


Do not dilute with water or hypotonic agents (may result in disruption of liposomal particles). Do not mix with lidocaine or other non-bupivacaine-based local anesthetics. Do not administer other forms of bupivacaine within 96hrs following administration of Exparel. May administer after at least 20 mins following local administration of lidocaine. Bupivacaine HCl, when injected immediately before or admixed with Exparel, may impact the pharmacokinetic and/or physicochemical properties of the drugs; may be admixed simultaneously or inject bupivacaine HCl immediately before Exparel as long as the mg dose ratio of bupivacaine HCl to Exparel does not exceed 1:2. Avoid contact with antiseptics (eg, povidone iodine).

Pharmacological Class:

Local anesthetic (amide-type).

Adverse Reactions:

Nausea, constipation, vomiting, pyrexia, dizziness, edema peripheral, anemia, hypotension, pruritus, tachycardia, headache, insomnia, anemia postoperative, muscle spasms, hemorrhagic anemia, back pain, somnolence, and procedural pain; CNS effects (eg, excitation, depression, restlessness, anxiety, tremors), cardiovascular effects (eg, decreased cardiac output, AV block, ventricular arrhythmias, cardiac arrest), allergic-type reactions, neurologic effects (eg, paresthesia, weakness, paralysis).

How Supplied:

Single-use vial (20mL)—10