Etoposide Capsules Rx

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Etoposide Capsules

Respiratory and thoracic cancers
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Generic Name and Formulations:

Etoposide 50mg; contain parabens.

Select therapeutic use:

Indications for Etoposide Capsules:

Small cell lung cancer.

Adult:

Round dose to nearest 50mg increment. Range: 70mg/m2 per day for 4 days to 100mg/m2 per day for 5 days. Repeat course every 3 to 4 weeks after recovery (esp myelosuppression). Renal impairment (CrCl ≤50mL/min): reduce dose (see literature). Consider dose reduction with existing myelosuppression due to previous radiation or chemotherapy.

Children:

Not recommended.

Warnings/Precautions:

Monitor blood (esp CBC/differential, platelets, hemoglobin) before each cycle and during therapy; renal function. Withhold dose if platelet count <50,000/mm3 or ANC <500/mm3. Hypoalbuminemia. Elderly. Pregnancy (Cat.D); nursing mothers: not recommended.

Interactions:

Potentiated by cyclosporine. Additive toxicity with radiation, other cytotoxic therapies.

Pharmacological Class:

Topoisomerase inhibitor.

Adverse Reactions:

GI upset, mucositis, myelosuppression (esp. neutropenia, thrombocytopenia; may be fatal), alopecia, fever, infections, peripheral neurotoxicity; hypersensitivity reactions, acute leukemia (rare); others.

Note:

Formerly known under the brand name VePesid.

How Supplied:

Contact supplier.