Susceptible infections including upper and lower respiratory, skin and soft tissue, genitourinary, Legionnaires' disease, pertussis, listeriosis.
250mg every 6 hours, 500mg every 12 hours, or 333mg every 8 hours; max 4g/day; twice daily dosing max 1g/day. Legionnaires: 1–4g/day in divided doses.
30–50mg/kg/day in divided doses; max 100mg/kg/day.
Concomitant cisapride, pimozide.
Hepatic dysfunction. Myasthenia gravis. Pregnancy (Cat.B). Nursing mothers.
See Contraindications. May potentiate or be potentiated by drugs metabolized by CYP450 (e.g., carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, disopyramide, bromocriptine, valproate). May potentiate warfarin, triazolam, midazolam, methylprednisolone, digoxin, theophylline, ergotamine. Avoid use with statins (rhabdomyolysis).
GI upset, abdominal pain, anorexia, hepatic dysfunction, rash, superinfection; pseudomembranous colitis, (rare).
250mg—30, 40, 100, 500; 333mg—30, 100, 500; 500mg—100