Ergotamine tartrate + Caffeine Tablets Rx

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Ergotamine tartrate + Caffeine Tablets

Migraine and headache
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Generic Name and Formulations:

Ergotamine tartrate 1mg, caffeine 100mg; tabs.

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Indications for Ergotamine tartrate + Caffeine Tablets:

Migraine, migraine variants, cluster headaches.


2 tablets at onset of attack, then 1 tablet every ½ hour if needed; max 6 tabs/attack, 10 tabs/week.


Not recommended.


Peripheral vascular disease. Coronary heart disease. Hypertension. Hepatic or renal dysfunction. Sepsis. Concomitant potent CYP3A4 inhibitors (eg, ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) or other vasoconstrictors. Labor & delivery. Pregnancy (Cat.X).


Monitor for ergotism; do not exceed recommended dose. Nursing mothers: not recommended.

See Also:

Ergotamine tartrate + Caffeine Suppositories

Pharmacological Class:

Ergot alkaloid.


See Contraindications. Potentiated by CYP3A4 inhibitors (eg, protease inhibitors, macrolides, azole antifungals, saquinavir, nefazodone, fluoxetine, fluvoxamine, grapefruit juice, zileuton), propranolol, nicotine. Severe hypertension with sympathomimetics.

Adverse Reactions:

Vasoconstrictive complications or ergotism (eg, ischemia, cold extremities, vasospasm, ECG changes, hyper- or hypotension, numbness, gangrene, dizziness), precordial or muscle pain, tachycardia, bradycardia, nausea, vomiting, local edema, itching; rarely: retroperitoneal and pleuropulmonary fibrosis, cardiac valve fibrosis (chronic use).


Formerly known under the brand names Cafergot, Migergot.

How Supplied:

Contact supplier.