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Imaging agents
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Generic Name and Formulations:

Gadoxetate disodium 181.43mg/mL (0.25mol/L); soln for IV inj.

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Indications for EOVIST:

For IV use in T1-weighted magnetic resonance imaging (MRI) of the liver to detect and characterize lesions in adults with known or suspected focal liver disease.


Give as IV bolus inj at a rate of 2mL/sec; flush with saline after inj. 0.1mL/kg (0.025mmol/kg). See full labeling re: imaging guidelines.


Not established.


Chronic, severe kidney disease (GFR<30mL/min/1.73m2), acute kidney injury: increased risk of nephrogenic systemic fibrosis; avoid unless necessary, allow sufficient period of time for elimination prior to re-administration. Screen for acute kidney injury and other conditions that reduce renal function (eg, >60yrs, hypertension, diabetes). Severe renal or hepatic failure. Elevated bilirubin (>3mg/dL) or ferritin may reduce hepatic contrast effect; perform MRI no later than 60 mins following administration. History of asthma/allergic disorders. Anaphylactoid reaction possible (may be fatal); have emergency resuscitative equipment available. Avoid extravasation. Pregnancy (Cat.C). Nursing mothers.


Serum iron using complexometric methods may result in falsely high or low values for up to 24hrs.

Pharmacological Class:

Gadolinium-based contrast agent.

Adverse Reactions:

Headache, dizziness, dysgeusia, parosmia, increased blood pressure, flushing, respiratory disorders, vomiting, nausea, rash, pruritus, inj site reactions, feeling hot.

How Supplied:

Single-dose vials (10mL, 15mL)—5