Select the drug indication to add to your list


Only 4 drugs may be compared at once

Generic Name and Formulations:

Aprepitant 40mg, 80mg, 125mg; caps.

Select therapeutic use:

Indications for EMEND:

In combination with other antiemetic agents, in patients ≥12yrs of age for prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately to highly emetogenic cancer chemotherapy, including high-dose cisplatin. Prevention of post-op nausea and vomiting (PONV) in adults.


Swallow caps whole. Chemotherapy induced: ≥12yrs: give with corticosteroid and 5-HT3 antagonist (see full labeling). 125mg on Day 1; then 80mg on Days 2 and 3. Administer caps 1 hr prior to chemotherapy on Days 1, 2, and 3; if no chemotherapy is given on Days 2 and 3, then administer caps in the AM. PONV: ≥18yrs: 40mg within 3hrs prior to anesthesia.


Chemotherapy induced: <12yrs: use oral susp. PONV: <18yrs: not established.


Concomitant pimozide.


Not for chronic continuous use. Severe hepatic impairment. Pregnancy. Nursing mothers.


See Contraindications. Monitor, and caution with, CYP3A4 substrates, including chemotherapy agents (eg, ifosfamide, vinblastine, vincristine). Avoid concomitant moderate-to-strong CYP3A4 inhibitors (eg, azole antifungals, macrolides, nefazodone, ritonavir, nelfinavir, diltiazem) or strong CYP3A4 inducers (eg, carbamazepine, phenytoin, rifampin). Potentiates dexamethasone (reduce its dose by 50%), methylprednisolone (reduce its IV dose by 25% and its oral dose by 50%), midazolam, alprazolam, triazolam. May antagonize warfarin (closely monitor INR for 2 weeks after starting each regimen), other CYP2C9 substrates, oral contraceptives (use alternative or backup method during and for 1 month after last dose).

See Also:



Pharmacological Class:

Substance P/NK1 receptor antagonist.

Adverse Reactions:

Fatigue, diarrhea, asthenia, dyspepsia, abdominal pain, hiccups, WBC count decreased, dehydration, ALT/AST increased, neutropenia, headache, anorexia, cough, hemoglobin decreased, dizziness, constipation, hypotension. Injection: inj site pain.

Generic Availability:


How Supplied:

Caps 40mg—1, 5; 80mg, 125mg—6; Bi-fold pack (2 x 80mg)—1; Tri-fold pack (1 x 125mg + 2 x 80mg)—1; Susp kit—1 (w. oral dispensers, supplies); Vial—1

EMEND 40mg capsules (Qty:1)

appx. price $117.00