EFFEXOR
Generic Name for EFFEXOR
Venlafaxine (as HCl) 25mg, 37.5mg, 50mg, 75mg, 100mg; scored tabs.
Legal Classification:
Rx
Pharmacological Class for EFFEXOR
Serotonin and norepinephrine reuptake inhibitor.
Manufacturer of EFFEXOR
Pfizer Labs
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Indications for EFFEXOR
Depression.
Adult dose for EFFEXOR
Take with food. ≥18yrs: Initially 75mg/day in 2–3 divided doses; may increase at 4-day intervals in 75mg/day increments to 150mg/day; max 375mg/day, in 3 divided doses. Hepatic impairment: reduce by at least 50%. Mild-to-moderate renal impairment: reduce by at least 25%; hemodialysis: reduce by 50% (hold dose until end of dialysis treatment). Withdraw gradually (over 2 weeks).
Children's dosing for EFFEXOR
<18 yrs: not recommended.
Also:
Contraindications for EFFEXOR
MAOIs (see Interactions).
Warnings/Precautions for EFFEXOR
Monitor blood pressure; reduce dose or discontinue if elevated BP persists. Heart disease (eg, recent MI, heart failure). Hypercholesterolemia (consider monitoring in long-term use). Renal or hepatic dysfunction. Increased intraocular pressure. Diseases that affect metabolism or hemodynamic response (eg, hyperthyroidism). Mania. Seizure disorders. Reevaluate periodically. Suicidal ideation. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (Cat.C) (avoid 3rd trimester; see literature for effects on neonate). Nursing mothers: not recommended.
Interactions for EFFEXOR
Allow at least 14 days after MAOI discontinuance before starting venlafaxine; allow at least 7 days after venlafaxine discontinuance before starting an MAOI. Avoid alcohol. Concomitant weight loss agents (eg, phentermine), serotonin precursors (tryptophan supplements): not recommended. Monitor for serotonin syndrome with SSRIs, SNRIs, triptans (esp. during initiation and dose increases). Caution with other CNS drugs, cimetidine, haloperidol, diuretics, drugs that inhibit both CYP2D6 and CYP3A4.
Adverse Reactions for EFFEXOR
GI upset, dizziness, somnolence, insomnia, sexual dysfunction, sweating, dry mouth, nervousness, asthenia, tremor, vasodilation, hypertension, abnormal dreams or vision, yawn, paresthesia, agitation, ecchymosis, anorexia, weight changes; hyponatremia/SIADH (esp in elderly).
How is EFFEXOR supplied?
Caps, tabs—100
Related Disease:
Depression