Take after meals. Initially 100mg twice daily; max 300mg daily.
Diuretic (K+ sparing).
Concomitant K+ supplements, K+-sparing diuretics, salt substitutes. Hyperkalemia. Anuria. Renal impairment. Severe hepatic disease.
Diabetes. Severely ill. Acidosis predisposition. Electrolyte imbalance. History of renal stones. Gout. Hepatic impairment. Monitor blood, electrolytes, hepatic and renal function frequently. Discontinue if serum potassium >5.5mEq/L or renal values progress. ECG changes or arrhythmias require prompt treatment. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Avoid K+-sparing diuretics, K+ supplements, and K+ containing salt substitutes. Lithium toxicity. Hyperkalemia more likely with ACE inhibitors. Hyponatremia with sulfonylureas. Acute renal failure with NSAIDs. Adjust antidiabetic medications. Potentiates antihypertensives, nondepolarizing muscle relaxants, anesthetics.
Rarely: anaphylaxis, rash, photosensitivity, hyper- or hypokalemia, azotemia, renal stones, acute interstitial nephritis, jaundice, GI upset, electrolyte disturbances, blood dyscrasias, weakness, fatigue, dizziness, dry mouth.