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DYAZIDE
Edema
Hypertension
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Drug Name:

DYAZIDE Rx

Generic Name and Formulations:
Triamterene 37.5mg, hydrochlorothiazide 25mg; caps.

Company:
GlaxoSmithKline Pharmaceuticals

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for DYAZIDE:

Edema.

Adult Dose for DYAZIDE:

1–2 caps once daily.

Children's Dose for DYAZIDE:

Not recommended.

Pharmacological Class:

K+-sparing + thiazide.

Contraindications:

Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.

Warnings/Precautions:

Diabetes. Acidosis predisposition. Electrolyte imbalance. Hypochloremia with metabolic alkalosis. Excess diuresis. History of renal stones. Gout. Surgery. SLE. Monitor electrolytes, renal function. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Severely ill. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digoxin, lithium toxicity. Hyperkalemia more likely with ACE inhibitors, parenteral penicillin G. Hypokalemia with ACTH, corticosteroids, amphotericin B. Hyponatremia with sulfonylureas. NSAIDs may cause renal failure. Adjust antidiabetic, antigout medications. May potentiate nondepolarizing muscle relaxants, antihypertensives. Antagonizes oral anticoagulants, methenamine. May interfere with parathyroid tests.

Adverse Reactions:

Drowsiness, muscle cramps, weakness, headache, GI disturbances, dizziness, impotence, arrhythmias, hypotension, dry mouth, urine discoloration.

How Supplied:

Caps—100, 1000

Indications for DYAZIDE:

Hypertension when normokalemia is essential.

Adult Dose for DYAZIDE:

1–2 caps once daily.

Children's Dose for DYAZIDE:

Not recommended.

Pharmacological Class:

Diuretic combination.

Contraindications:

Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.

Warnings/Precautions:

Diabetes. Acidosis predisposition. Electrolyte imbalance. Hypochloremia with metabolic alkalosis. Excess diuresis. History of renal stones. Gout. Surgery. SLE. Monitor electrolytes, renal function. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Severely ill. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digoxin, lithium toxicity. Hyperkalemia more likely with ACE inhibitors, parenteral penicillin G. Hypokalemia with ACTH, corticosteroids, amphotericin B. Hyponatremia with sulfonylureas. NSAIDs may cause renal failure. Adjust antidiabetic, antigout medications. May potentiate nondepolarizing muscle relaxants, antihypertensives. Antagonizes oral anticoagulants, methenamine. May interfere with parathyroid tests.

Adverse Reactions:

Drowsiness, muscle cramps, weakness, headache, GI disturbances, dizziness, impotence, arrhythmias, hypotension, dry mouth, urine discoloration.

How Supplied:

Caps—100, 1000