Phase 3 study of axitinib for the treatment of metastatic renal cell carcinoma (mRCC)

Pfizer announced results from its Phase 3 study of axitinib for the treatment of metastatic renal cell carcinoma (mRCC) in previously treated patients. This trial met its primary endpoint, demonstrating that axitinib significantly extended progression-free survival (PFS) when compared to sorafenib, in the study population. Consistent with previous analyses, axitinib demonstrated a generally manageable safety profile in this study.

Axitinib is an oral and selective inhibitor of vascular endothelial growth factor (VEGF) receptors 1, 2 and 3. VEGF receptors 1, 2 and 3 appear to have roles in tumor growth, vascular angiogenesis and metastatic progression of cancer (the spread of tumors).

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